Doing more with less: Evaluation of the use of high linear velocities in preparative supercritical fluid chromatography.

Chemistry Techniques, Analytical / economics Chromatography, Supercritical Fluid Pressure Solvents / chemistry Stereoisomerism
Chiral Chromatography Flow optimization Preparative Purifications SFC

Journal

Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488

Informations de publication

Date de publication:
21 Jun 2019
Historique:
received: 29 06 2018
revised: 22 01 2019
accepted: 21 02 2019
pubmed: 16 3 2019
medline: 6 7 2019
entrez: 16 3 2019
Statut: ppublish

Résumé

The evaluation of higher than typical linear velocities is discussed for supercritical fluid chromatographic purifications on the preparative scale. SFC separation efficiency suffers far less at high linear velocities than HPLC by the rapid mass transfer of analytes carried by compressed CO

Identifiants

DOI: 10.1016/j.chroma.2019.02.047 PMID: 30871755
pubmed: 30871755
pii: S0021-9673(19)30195-5
doi: 10.1016/j.chroma.2019.02.047
pii:
doi:

Substances chimiques

Solvents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

199-206

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Jimmy O DaSilva (JO)

Merck & Co., Inc., MRL, Rahway, NJ, 07065, USA. Electronic address: jimmy.dasilva@merck.com.

Raffeal Bennett (R)

Merck & Co., Inc., MRL, Rahway, NJ, 07065, USA.

Benjamin F Mann (BF)

Merck & Co., Inc., MRL, Rahway, NJ, 07065, USA.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Doing more with less: Evaluation of the use of...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase supercritique › Doing more with less: Evaluation of the use of...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Pression › Doing more with less: Evaluation of the use of...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solvants › Doing more with less: Evaluation of the use of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Doing more with less: Evaluation of the use of...