BTNL2 gene polymorphism and sarcoid uveitis.
genetics
immunology
inflammation
Journal
The British journal of ophthalmology
ISSN: 1468-2079
Titre abrégé: Br J Ophthalmol
Pays: England
ID NLM: 0421041
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
30
07
2018
revised:
16
01
2019
accepted:
20
02
2019
pubmed:
16
3
2019
medline:
30
5
2020
entrez:
16
3
2019
Statut:
ppublish
Résumé
Uveitis is a frequent and early feature of sarcoidosis. As BTNL2 (butyrophilin-like 2) gene polymorphism was found linked with the susceptibility to sarcoidosis, we investigated whether a specific genotype of BTNL2 gene G16071A (or rs2076530) single-nucleotide polymorphism (SNP) would be associated with the risk of sarcoid uveitis in all patient subgroups. The study compared the genotype frequencies of SNP G16071A of 135 patients with sarcoid uveitis (Sa A statistically significant difference in genotype frequencies was found between the groups Sa No association was found between G16071A and the susceptibility to sarcoid uveitis. BTNL2 gene G16071A SNP seems to be a predisposing factor for sarcoidosis except in Caucasian postmenopausal women with sarcoid uveitis in whom the GG genotype prevails. These and future results will help in understanding differences between particular subgroups of patients with sarcoid uveitis.
Sections du résumé
BACKGROUND
Uveitis is a frequent and early feature of sarcoidosis. As BTNL2 (butyrophilin-like 2) gene polymorphism was found linked with the susceptibility to sarcoidosis, we investigated whether a specific genotype of BTNL2 gene G16071A (or rs2076530) single-nucleotide polymorphism (SNP) would be associated with the risk of sarcoid uveitis in all patient subgroups.
METHODS
The study compared the genotype frequencies of SNP G16071A of 135 patients with sarcoid uveitis (Sa
RESULTS
A statistically significant difference in genotype frequencies was found between the groups Sa
CONCLUSION
No association was found between G16071A and the susceptibility to sarcoid uveitis. BTNL2 gene G16071A SNP seems to be a predisposing factor for sarcoidosis except in Caucasian postmenopausal women with sarcoid uveitis in whom the GG genotype prevails. These and future results will help in understanding differences between particular subgroups of patients with sarcoid uveitis.
Identifiants
pubmed: 30872286
pii: bjophthalmol-2018-312949
doi: 10.1136/bjophthalmol-2018-312949
doi:
Substances chimiques
BTNL2 protein, human
0
Butyrophilins
0
DNA Primers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1690-1694Informations de copyright
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.