Extrachromosomal oncogene amplification in tumour pathogenesis and evolution.
Journal
Nature reviews. Cancer
ISSN: 1474-1768
Titre abrégé: Nat Rev Cancer
Pays: England
ID NLM: 101124168
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
pubmed:
16
3
2019
medline:
21
5
2019
entrez:
16
3
2019
Statut:
ppublish
Résumé
Recent reports have demonstrated that oncogene amplification on extrachromosomal DNA (ecDNA) is a frequent event in cancer, providing new momentum to explore a phenomenon first discovered several decades ago. The direct consequence of ecDNA gains in these cases is an increase in DNA copy number of the oncogenes residing on the extrachromosomal element. A secondary effect, perhaps even more important, is that the unequal segregation of ecDNA from a parental tumour cell to offspring cells rapidly increases tumour heterogeneity, thus providing the tumour with an additional array of responses to microenvironment-induced and therapy-induced stress factors and perhaps providing an evolutionary advantage. This Perspectives article discusses the current knowledge and potential implications of oncogene amplification on ecDNA in cancer.
Identifiants
pubmed: 30872802
doi: 10.1038/s41568-019-0128-6
pii: 10.1038/s41568-019-0128-6
pmc: PMC7168519
mid: NIHMS1067253
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
283-288Subventions
Organisme : NCI NIH HHS
ID : R01 CA190121
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG004962
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA034196
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS073831
Pays : United States
Organisme : NIH HHS
ID : R01 CA190121
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM114362
Pays : United States
Organisme : NIH HHS
ID : P30CA034196
Pays : United States
Références
G3 (Bethesda). 2017 Oct 5;7(10):3295-3303
pubmed: 28801508
J Appl Genet. 2011 Feb;52(1):53-9
pubmed: 21107781
Nat Genet. 2017 Jan;49(1):65-74
pubmed: 27869826
Cancer Genet Cytogenet. 1987 Nov;29(1):165-70
pubmed: 3478127
Cell. 1981 Nov;26(3 Pt 1):355-62
pubmed: 7326744
Cancer Cell. 2011 Dec 13;20(6):810-7
pubmed: 22137795
Cell. 2017 Nov 30;171(6):1259-1271.e11
pubmed: 29107330
Cell. 1983 Dec;35(2 Pt 1):359-67
pubmed: 6197179
Genome Res. 2010 Sep;20(9):1198-206
pubmed: 20631050
Science. 2012 Apr 6;336(6077):82-6
pubmed: 22403181
Nature. 2016 Jan 7;529(7584):110-4
pubmed: 26700815
Mol Cell Biol. 1989 Jan;9(1):109-15
pubmed: 2648129
Lancet. 1965 Jul 10;1(7402):55-8
pubmed: 14304929
Nat Commun. 2018 Mar 14;9(1):1069
pubmed: 29540679
Genes Dev. 2013 Jul 1;27(13):1462-72
pubmed: 23796897
Microbiol Mol Biol Rev. 2003 Jun;67(2):277-301, table of contents
pubmed: 12794193
Science. 2013 Mar 29;339(6127):1546-58
pubmed: 23539594
Cancer Discov. 2018 Jun;8(6):730-749
pubmed: 29510987
Br J Pharmacol. 2008 Mar;153 Suppl 1:S347-57
pubmed: 18193080
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1648-52
pubmed: 377280
Acta Neuropathol. 2019 Jan;137(1):123-137
pubmed: 30267146
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3041-6
pubmed: 22323597
Science. 2016 Mar 25;351(6280):1454-1458
pubmed: 26940867
Science. 2014 Jan 3;343(6166):72-6
pubmed: 24310612
Cancer Res. 1991 Dec 1;51(23 Pt 1):6273-9
pubmed: 1682044
Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):E3114-22
pubmed: 26038577
PLoS One. 2013;8(2):e56185
pubmed: 23441165
Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11368-73
pubmed: 15269346
Nucleic Acids Res. 2014 Aug;42(14):9131-45
pubmed: 25034695
Science. 1991 Nov 22;254(5035):1153-60
pubmed: 1957167
Nature. 2010 Feb 18;463(7283):899-905
pubmed: 20164920
Nat Biotechnol. 2009 Dec;27(12):1181-5
pubmed: 19935656
Cell. 2013 Apr 11;153(2):307-19
pubmed: 23582322
Cytogenet Genome Res. 2004;107(1-2):55-67
pubmed: 15305057
Cell. 2018 Jun 14;173(7):1755-1769.e22
pubmed: 29754820
Trends Cell Biol. 2017 Dec;27(12):917-930
pubmed: 28899600
Trends Genet. 2018 Apr;34(4):270-278
pubmed: 29329720
Science. 2018 Oct 26;362(6413):
pubmed: 30361341
Mol Cell Biol. 1988 Apr;8(4):1525-33
pubmed: 2898098
Nature. 2017 Mar 2;543(7643):122-125
pubmed: 28178237
Nat Rev Cancer. 2008 Jan;8(1):56-61
pubmed: 18059462
Cell. 2013 Mar 28;153(1):17-37
pubmed: 23540688
Proc Natl Acad Sci U S A. 1965 Feb;53:356-62
pubmed: 14294069
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6142-6
pubmed: 118461
Nat Commun. 2019 Jan 23;10(1):392
pubmed: 30674876
J Biol Chem. 1981 Sep 25;256(18):9501-10
pubmed: 7287696
Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8165-9
pubmed: 1518843
Cancer Cell. 2018 Aug 13;34(2):197-210.e5
pubmed: 30017478
Nat Genet. 2018 May;50(5):708-717
pubmed: 29686388
Proc Natl Acad Sci U S A. 1983 Mar;80(6):1707-11
pubmed: 6300869
Oncogene. 1997 Feb 27;14(8):977-85
pubmed: 9050997
Nat Commun. 2014 Dec 04;5:5690
pubmed: 25471132
Cell. 1984 Sep;38(2):431-9
pubmed: 6467372
Genome Res. 2013 May;23(5):762-76
pubmed: 23410887
Nature. 2012 Apr 11;485(7398):376-80
pubmed: 22495300
Genetics. 2018 Mar;208(3):951-961
pubmed: 29279323
Cell. 1984 Jul;37(3):705-13
pubmed: 6378386
Nucleic Acids Res. 2018 Dec 14;46(22):e131
pubmed: 30551175
Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20489-93
pubmed: 21059955
Cell. 2013 Mar 14;152(6):1226-36
pubmed: 23498933
Cell. 2015 Aug 13;162(4):911-23
pubmed: 26276637
Nat Rev Cancer. 2007 Apr;7(4):233-45
pubmed: 17361217
J Biol Chem. 1978 Mar 10;253(5):1357-70
pubmed: 627542
Cell. 1989 Jun 16;57(6):901-8
pubmed: 2661014
Hum Mol Genet. 2006 Mar 15;15(6):933-42
pubmed: 16452126
Cancer Cell. 2014 Nov 10;26(5):653-67
pubmed: 25517748
Nat Med. 2017 Aug;23(8):929-937
pubmed: 28714990