Low-Dose Total Body Irradiation Can Enhance Systemic Immune Related Response Induced by Hypo-Fractionated Radiation.
hypo-fractionated radiation therapy
immune enhancement
immunosuppressive microenvironment
low-dose total body irradiation
systemic immune related response
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
11
09
2018
accepted:
06
02
2019
entrez:
16
3
2019
pubmed:
16
3
2019
medline:
18
9
2020
Statut:
epublish
Résumé
A systemic immune related response (SIME) of radiotherapy has been occasionally observed on metastatic tumors, but the clinical outcomes remain poor. Novel treatment approaches are therefore needed to improve SIME ratio. We used a combination of hypo-fractionated radiation therapy (H-RT) with low-dose total body irradiation (L-TBI) in a syngeneic mouse model of breast and colon carcinoma. The combination therapy of H-RT and L-TBI potentially enhanced SIME by infiltration of CD8
Identifiants
pubmed: 30873170
doi: 10.3389/fimmu.2019.00317
pmc: PMC6401363
doi:
Substances chimiques
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
317Commentaires et corrections
Type : ErratumIn
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