Embryotoxicity of ozonated diclofenac, carbamazepine, and oxazepam in zebrafish (Danio rerio).

Animals Carbamazepine / chemistry Diclofenac / chemistry Oxazepam / chemistry Ozone / chemistry Sewage / chemistry Water Pollutants, Chemical / chemistry Zebrafish / embryology
Developmental toxicity OBP Ozonation Ozonation by-products Ozone removal efficiency Pharmaceuticals

Journal

Chemosphere
ISSN: 1879-1298
Titre abrégé: Chemosphere
Pays: England
ID NLM: 0320657

Informations de publication

Date de publication:
Jun 2019
Historique:
received: 18 12 2018
revised: 05 03 2019
accepted: 06 03 2019
pubmed: 16 3 2019
medline: 7 6 2019
entrez: 16 3 2019
Statut: ppublish

Résumé

Pharmaceutical residues are polluting the surface water environments worldwide. Sewage and wastewater treatment, therefore, needs to be improved in order to remove pharmaceutical residues from the effluent. One such treatment improvement is effluent ozonation. Even though ozonation has proven to be very efficient in reducing pharmaceutical parent compound concentrations in wastewater effluents, much remains unclear regarding potentially toxic ozonation by-product (OBP) formation. In this study, we sought to elucidate the aquatic toxicity of ozonated pharmaceuticals in zebrafish (Danio rerio) embryos in a static 144 h post fertilization (hpf) fish embryotoxicity (ZFET) assay. Three pharmaceuticals commonly detected in wastewater effluents, i.e. carbamazepine, diclofenac, and oxazepam, were selected for testing. Toxicity was assessed before and after 1 min ozonation (0.053 mg L

Identifiants

DOI: 10.1016/j.chemosphere.2019.03.034 PMID: 30875502
pubmed: 30875502
pii: S0045-6535(19)30470-9
doi: 10.1016/j.chemosphere.2019.03.034
pii:
doi:

Substances chimiques

Sewage 0
Water Pollutants, Chemical 0
Diclofenac 144O8QL0L1
Carbamazepine 33CM23913M
Ozone 66H7ZZK23N
Oxazepam 6GOW6DWN2A

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

191-199

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Johannes Pohl (J)

Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden. Electronic address: johannes.pohl@slu.se.

Lutz Ahrens (L)

Section for Organic Environmental Chemistry and Ecotoxicology, Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Gunnar Carlsson (G)

Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Oksana Golovko (O)

Section for Geochemistry and Hydrology, Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Leif Norrgren (L)

Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Jana Weiss (J)

Section for Organic Environmental Chemistry and Ecotoxicology, Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Stefan Örn (S)

Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Embryotoxicity of ozonated diclofenac,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Dibenzazépines › Carbamazépine › Embryotoxicity of ozonated diclofenac,...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Phénylacétates › Diclofenac › Embryotoxicity of ozonated diclofenac,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Benzodiazépinones › Oxazépam › Embryotoxicity of ozonated diclofenac,...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › Ozone › Embryotoxicity of ozonated diclofenac,...
questionsmedicales.fr › Mélanges complexes › Eaux d'égout › Embryotoxicity of ozonated diclofenac,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants de l'eau › Polluants chimiques de l'eau › Embryotoxicity of ozonated diclofenac,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Embryotoxicity of ozonated diclofenac,...