Genomic basis of delayed reward discounting.
Delayed reward discounting
Genetics
Genomics
Impulsivity
Journal
Behavioural processes
ISSN: 1872-8308
Titre abrégé: Behav Processes
Pays: Netherlands
ID NLM: 7703854
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
14
11
2018
revised:
04
03
2019
accepted:
09
03
2019
pubmed:
17
3
2019
medline:
6
6
2019
entrez:
17
3
2019
Statut:
ppublish
Résumé
Delayed reward discounting (DRD) is a behavioral economic measure of impulsivity, reflecting how rapidly a reward loses value based on its temporal distance. In humans, more impulsive DRD is associated with susceptibility to a number of psychiatric diseases (e.g., addiction, ADHD), health outcomes (e.g., obesity), and lifetime outcomes (e.g., educational attainment). Although the determinants of DRD are both genetic and environmental, this review focuses on its genetic basis. Both rodent studies using inbred strains and human twin studies indicate that DRD is moderately heritable, a conclusion that was further supported by a recent human genome-wide association study (GWAS) that used single nucleotide polymorphisms (SNP) to estimate heritability. The GWAS of DRD also identified genetic correlations with psychiatric diagnoses, health outcomes, and measures of cognitive performance. Future research priorities include rodent studies probing putative genetic mechanisms of DRD and human GWASs using larger samples and non-European cohorts. Continuing to characterize genomic influences on DRD has the potential to yield important biological insights with implications for a variety of medically and socially important outcomes.
Identifiants
pubmed: 30876880
pii: S0376-6357(18)30470-4
doi: 10.1016/j.beproc.2019.03.006
pmc: PMC6980721
mid: NIHMS1547096
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
157-161Subventions
Organisme : NIDA NIH HHS
ID : R01 DA037011
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA032015
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA025849
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA037844
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA002812
Pays : United States
Organisme : NIAAA NIH HHS
ID : K24 AA022136
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA025911
Pays : United States
Organisme : NIMH NIH HHS
ID : R25 MH081482
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA024930
Pays : United States
Informations de copyright
Published by Elsevier B.V.
Références
Behav Processes. 2014 Sep;107:99-105
pubmed: 25139835
Nat Genet. 2015 Jul;47(7):702-9
pubmed: 25985137
Behav Pharmacol. 2009 Sep;20(5-6):380-9
pubmed: 19667970
Neuropsychopharmacology. 2013 Apr;38(5):802-16
pubmed: 23303064
Neuropsychologia. 2018 Mar;111:344-359
pubmed: 29438672
Diabetes Metab. 2011 Dec;37(6):497-504
pubmed: 21550831
Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Jul;1(4):316-325
pubmed: 27722208
Behav Neurosci. 2014 Aug;128(4):419-29
pubmed: 24841739
Am J Hum Genet. 2017 Jul 6;101(1):5-22
pubmed: 28686856
Nat Genet. 2015 Oct;47(10):1114-20
pubmed: 26323059
Nature. 2017 Feb 9;542(7640):186-190
pubmed: 28146470
Psychol Med. 2016 Aug;46(11):2423-34
pubmed: 27299672
Genes Brain Behav. 2013 Jul;12(5):490-502
pubmed: 23710681
J Neurosci. 2019 Mar 27;39(13):2562-2572
pubmed: 30718321
Biol Psychiatry. 2014 Mar 15;75(6):435-48
pubmed: 24041504
Exp Clin Psychopharmacol. 2003 May;11(2):139-45
pubmed: 12755458
Psychol Sci. 2016 Feb;27(2):138-149
pubmed: 26671911
Biol Psychiatry. 2015 May 15;77(10):887-94
pubmed: 25555481
Psychopharmacology (Berl). 2016 Sep;233(18):3361-70
pubmed: 27449350
J Exp Anal Behav. 1997 May;67(3):353-66
pubmed: 9163939
Philos Trans R Soc Lond B Biol Sci. 2019 Feb 18;374(1766):20180145
pubmed: 30966923
J Exp Psychol Gen. 1999 Mar;128(1):78-87
pubmed: 10100392
Exp Clin Psychopharmacol. 2014 Oct;22(5):434-43
pubmed: 24999868
Psychol Med. 2018 Dec;48(16):2702-2709
pubmed: 29463327
J Exp Psychol Anim Learn Cogn. 2016 Apr;42(2):141-62
pubmed: 26881899
Alcohol Clin Exp Res. 2018 Oct;42(10):2033-2046
pubmed: 30152855
J Neurosci. 2004 Jul 28;24(30):6733-40
pubmed: 15282276
Neuroscience. 2015 Jul 23;299:1-17
pubmed: 25934039
J Exp Anal Behav. 2004 Jan;81(1):39-50
pubmed: 15113132
Eur J Epidemiol. 2015 Jul;30(7):543-52
pubmed: 25773750
Dev Psychopathol. 2018 May;30(2):417-435
pubmed: 28606210
Behav Processes. 2018 Apr;149:8-15
pubmed: 29366752
Behav Neurosci. 2007 Jun;121(3):543-9
pubmed: 17592945
J Exp Anal Behav. 2016 Sep;106(2):156-63
pubmed: 27644448
Front Psychol. 2015 Sep 01;6:1104
pubmed: 26388788
Behav Processes. 2003 Oct 31;64(3):305-313
pubmed: 14580700
Behav Processes. 2006 Nov 1;73(3):278-84
pubmed: 16926071
J Exp Anal Behav. 2001 Sep;76(2):235-43
pubmed: 11599641
Curr Protoc Neurosci. 2014 Jan 15;66:Unit 8.30.
pubmed: 24510779
Psychiatry Res. 2018 Jan;259:398-404
pubmed: 29120849
Exp Clin Psychopharmacol. 2019 Feb;27(1):29-37
pubmed: 30265060
Psychopharmacology (Berl). 2011 Aug;216(3):305-21
pubmed: 21373791
Pharmacol Biochem Behav. 2005 Mar;80(3):387-93
pubmed: 15740780
Transl Psychiatry. 2019 Jan 18;9(1):25
pubmed: 30659167
Mol Psychiatry. 2018 Jul;23(7):1590-1596
pubmed: 28696435
Psychon Bull Rev. 2009 Dec;16(6):1071-5
pubmed: 19966257
Addiction. 2017 Jan;112(1):51-62
pubmed: 27450931
Neuropsychopharmacology. 2018 Sep;43(10):1985-1988
pubmed: 29844475
Cell. 2017 Jun 15;169(7):1177-1186
pubmed: 28622505
Exp Clin Psychopharmacol. 2014 Jun;22(3):222-8
pubmed: 24708144
Psychol Sci. 2012;23(11):1314-23
pubmed: 23012269
Nat Genet. 2012 Apr 15;44(5):552-61
pubmed: 22504417
Nat Commun. 2018 Jun 1;9(1):2048
pubmed: 29858574
Pharmacol Biochem Behav. 2018 Jan;164:106-117
pubmed: 28778737
Addict Behav. 2014 Nov;39(11):1632-9
pubmed: 24864028
Neurosci Biobehav Rev. 2017 Dec;83:440-450
pubmed: 28928071
Psychol Bull. 2004 Sep;130(5):769-92
pubmed: 15367080
Genes Brain Behav. 2009 Jun;8(4):426-34
pubmed: 19243451
Drug Alcohol Depend. 2018 Jan 1;182:8-18
pubmed: 29120861
Nat Neurosci. 2018 Jan;21(1):16-18
pubmed: 29230059
Behav Processes. 2016 Nov;132:42-48
pubmed: 27663668
Exp Clin Psychopharmacol. 2017 Dec;25(6):512-520
pubmed: 29251981
Nat Rev Drug Discov. 2014 Jun;13(6):419-31
pubmed: 24833294
Behav Genet. 2011 Mar;41(2):175-83
pubmed: 20700643
Nat Rev Genet. 2008 May;9(5):356-69
pubmed: 18398418
Behav Brain Res. 2015 Jan 15;277:254-63
pubmed: 24768641
J Exp Anal Behav. 2002 Mar;77(2):129-46
pubmed: 11936247
J Exp Anal Behav. 2008 Nov;90(3):333-44
pubmed: 19070340
Nat Genet. 2015 Aug;47(8):856-60
pubmed: 26121088
Behav Processes. 2014 Oct;108:50-6
pubmed: 25225037
Behav Genet. 2014 Mar;44(2):102-12
pubmed: 24442381
Behav Processes. 2013 Nov;100:116-22
pubmed: 23954833
Med Decis Making. 2010 Jan-Feb;30(1):99-112
pubmed: 19675322
Behav Neurosci. 2010 Aug;124(4):470-7
pubmed: 20695646
J Mol Neurosci. 2009 Mar;37(3):191-200
pubmed: 18581270
Psychol Med. 2019 Jan;49(2):190-199
pubmed: 30070191
Mol Psychiatry. 2018 Mar;23(3):666-673
pubmed: 28439101
Mol Psychiatry. 2015 May;20(5):555-62
pubmed: 25754081
Nature. 2015 Feb 12;518(7538):197-206
pubmed: 25673413