Tumor dormancy at bedside: A late awakening.
Adult
Aged
Axilla
Breast Neoplasms
/ mortality
Chemotherapy, Adjuvant
/ mortality
Combined Modality Therapy
Disease-Free Survival
Female
Humans
Lymph Nodes
/ pathology
Mastectomy
/ mortality
Middle Aged
Neoplasm Recurrence, Local
/ etiology
Postoperative Period
Randomized Controlled Trials as Topic
Risk Assessment
Risk Factors
Time Factors
Tumor Burden
Breast cancer
Late recurrences
Recurrence dynamics
Tumor dormancy
Tumor homeostasis
Journal
Breast (Edinburgh, Scotland)
ISSN: 1532-3080
Titre abrégé: Breast
Pays: Netherlands
ID NLM: 9213011
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
12
01
2019
revised:
28
02
2019
accepted:
01
03
2019
pubmed:
18
3
2019
medline:
4
12
2019
entrez:
18
3
2019
Statut:
ppublish
Résumé
Breast cancer recurrence may occur at variable times following primary tumor removal. The corresponding event dynamics displays a structured multipeak pattern, which can be explained by the occurrence of microscopic phases of metastasis quiescence (tumor dormancy) followed by wake up, growth and timed clinical appearance. This model provides a meaningful justification of the early recurrence pattern and even explains the effectiveness of adjuvant systemic therapies. Yet, late recurrences, which were less investigated, are fairly little known and a few researchers supported their steady state appearance. We report here the analysis of the late clinical course from patients who were disease-free at 5 years of follow-up, which again displays a structured pattern, supporting the view that tumor dormancy can explain the late recurrence risk as well. Tailored treatments are needed to address late clinical recurrences.
Identifiants
pubmed: 30878882
pii: S0960-9776(19)30040-2
doi: 10.1016/j.breast.2019.03.001
pii:
doi:
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
61-63Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.