The transcriptional profile of circulating myeloid derived suppressor cells correlates with tumor development and progression in mouse.

Animals CD11b Antigen / analysis Disease Progression Mice Mice, Inbred BALB C Mice, Inbred C57BL Myeloid Cells / metabolism Myeloid-Derived Suppressor Cells / metabolism Neoplasms / immunology Transcriptome / genetics

Journal

Genes and immunity
ISSN: 1476-5470
Titre abrégé: Genes Immun
Pays: England
ID NLM: 100953417

Informations de publication

Date de publication:
09 2019
Historique:
received: 06 12 2018
accepted: 25 02 2019
revised: 13 02 2019
pubmed: 19 3 2019
medline: 28 1 2020
entrez: 19 3 2019
Statut: ppublish

Résumé

Myeloid derived suppressor cells (MDSCs) play key roles in cancer development. Accumulation of peripheral-blood MDSCs (PB-MDSCs) corresponds to the progression of various cancers, but provides only a crude indicator. We aimed toward identifying changes in the transcriptional profile of PB-MDSCs in response to tumor growth. CT26 colon cancer cells and B16 melanoma cells (10

Identifiants

DOI: 10.1038/s41435-019-0062-3 PMID: 30880333
pubmed: 30880333
doi: 10.1038/s41435-019-0062-3
pii: 10.1038/s41435-019-0062-3
doi:

Substances chimiques

CD11b Antigen 0
Itgam protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

589-598

Auteurs

Ido Nachmany (I)

The Laboratory of Molecular Genetics, HPB Cancer Research, Department of Surgery B, the Surgical Division, Tel-Aviv Sourasky Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Yoel Bogoch (Y)

The Laboratory of Molecular Genetics, HPB Cancer Research, Department of Surgery B, the Surgical Division, Tel-Aviv Sourasky Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Gilgi Friedlander-Malik (G)

Ilana and Pascal Mantoux Institute for Bioinformatics, Nancy and Stephen Grand Israel National Center for Personalized Medicine, The Weizmann Institute of Science, Rehovot, Israel.

Omer Amar (O)

The Laboratory of Molecular Genetics, HPB Cancer Research, Department of Surgery B, the Surgical Division, Tel-Aviv Sourasky Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Ekaterina Bondar (E)

The Laboratory of Molecular Genetics, HPB Cancer Research, Department of Surgery B, the Surgical Division, Tel-Aviv Sourasky Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Nitzan Zohar (N)

The Laboratory of Molecular Genetics, HPB Cancer Research, Department of Surgery B, the Surgical Division, Tel-Aviv Sourasky Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Shay Hantisteanu (S)

Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel.

Ofer Fainaru (O)

IVF Unit, Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel.

Nir Lubezky (N)

The Laboratory of Molecular Genetics, HPB Cancer Research, Department of Surgery B, the Surgical Division, Tel-Aviv Sourasky Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Joseph M Klausner (JM)

The Laboratory of Molecular Genetics, HPB Cancer Research, Department of Surgery B, the Surgical Division, Tel-Aviv Sourasky Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Niv Pencovich (N)

The Laboratory of Molecular Genetics, HPB Cancer Research, Department of Surgery B, the Surgical Division, Tel-Aviv Sourasky Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Nivp@tlvmc.gov.il.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The transcriptional profile of circulating...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Antigènes CD11 › Antigènes CD11b › The transcriptional profile of circulating...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › The transcriptional profile of circulating...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The transcriptional profile of circulating...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › The transcriptional profile of circulating...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › The transcriptional profile of circulating...
questionsmedicales.fr › Cellules › Cellules myéloïdes › The transcriptional profile of circulating...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Cellules myéloïdes suppressives › The transcriptional profile of circulating...
questionsmedicales.fr › Tumeurs › The transcriptional profile of circulating...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › The transcriptional profile of circulating...