Pesticide use and risk of non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH consortium.
Age of Onset
Aged
Aged, 80 and over
Agriculture
Case-Control Studies
Female
France
/ epidemiology
Humans
Lymphoma, Non-Hodgkin
/ epidemiology
Male
Middle Aged
Norway
/ epidemiology
Occupational Exposure
/ statistics & numerical data
Pesticides
Regression Analysis
Risk Factors
United States
/ epidemiology
AGRICOH
NHL
Pesticides
cohort
farmers
meta-analysis
Journal
International journal of epidemiology
ISSN: 1464-3685
Titre abrégé: Int J Epidemiol
Pays: England
ID NLM: 7802871
Informations de publication
Date de publication:
01 10 2019
01 10 2019
Historique:
accepted:
04
02
2019
pubmed:
19
3
2019
medline:
21
4
2020
entrez:
19
3
2019
Statut:
ppublish
Résumé
Pesticides are commonly used in agriculture, and previous studies endorsed the need to further investigate the possible association between their use and risk of lymphoid malignancies in agricultural workers. We investigated the relationship of ever use of 14 selected pesticide chemical groups and 33 individual active chemical ingredients with non-Hodgkin lymphoid malignancies (NHL) overall or major subtypes, in a pooled analysis of three large agricultural worker cohorts. Pesticide use was derived from self-reported history of crops cultivated combined with crop-exposure matrices (France and Norway) or self-reported lifetime use of active ingredients (USA). Cox regression models were used to estimate cohort-specific hazard ratios (HRs) and 95% confidence intervals (CIs), which were combined using random effects meta-analysis to calculate meta-HRs. During follow-up, 2430 NHL cases were diagnosed in 316 270 farmers accruing 3 574 815 person-years under risk. Most meta-HRs suggested no association. Moderately elevated meta-HRs were seen for: NHL and ever use of terbufos (meta-HR = 1.18, 95% CI: 1.00-1.39); chronic lymphocytic leukaemia/small lymphocytic lymphoma and deltamethrin (1.48, 1.06-2.07); and diffuse large B-cell lymphoma and glyphosate (1.36, 1.00-1.85); as well as inverse associations of NHL with the broader groups of organochlorine insecticides (0.86, 0.74-0.99) and phenoxy herbicides (0.81, 0.67-0.98), but not with active ingredients within these groups, after adjusting for exposure to other pesticides. Associations of pesticides with NHL appear to be subtype- and chemical-specific. Non-differential exposure misclassification was an important limitation, showing the need for refinement of exposure estimates and exposure-response analyses.
Sections du résumé
BACKGROUND
Pesticides are commonly used in agriculture, and previous studies endorsed the need to further investigate the possible association between their use and risk of lymphoid malignancies in agricultural workers.
METHODS
We investigated the relationship of ever use of 14 selected pesticide chemical groups and 33 individual active chemical ingredients with non-Hodgkin lymphoid malignancies (NHL) overall or major subtypes, in a pooled analysis of three large agricultural worker cohorts. Pesticide use was derived from self-reported history of crops cultivated combined with crop-exposure matrices (France and Norway) or self-reported lifetime use of active ingredients (USA). Cox regression models were used to estimate cohort-specific hazard ratios (HRs) and 95% confidence intervals (CIs), which were combined using random effects meta-analysis to calculate meta-HRs.
RESULTS
During follow-up, 2430 NHL cases were diagnosed in 316 270 farmers accruing 3 574 815 person-years under risk. Most meta-HRs suggested no association. Moderately elevated meta-HRs were seen for: NHL and ever use of terbufos (meta-HR = 1.18, 95% CI: 1.00-1.39); chronic lymphocytic leukaemia/small lymphocytic lymphoma and deltamethrin (1.48, 1.06-2.07); and diffuse large B-cell lymphoma and glyphosate (1.36, 1.00-1.85); as well as inverse associations of NHL with the broader groups of organochlorine insecticides (0.86, 0.74-0.99) and phenoxy herbicides (0.81, 0.67-0.98), but not with active ingredients within these groups, after adjusting for exposure to other pesticides.
CONCLUSIONS
Associations of pesticides with NHL appear to be subtype- and chemical-specific. Non-differential exposure misclassification was an important limitation, showing the need for refinement of exposure estimates and exposure-response analyses.
Identifiants
pubmed: 30880337
pii: 5382278
doi: 10.1093/ije/dyz017
pmc: PMC6857760
doi:
Substances chimiques
Pesticides
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1519-1535Subventions
Organisme : Intramural NIH HHS
ID : Z01 CP010119
Pays : United States
Organisme : NCI NIH HHS
ID : Z01 CP010119
Pays : United States
Informations de copyright
© World Health Organization, 2019. All rights reserved. The World Health Organization has granted the Publisher permission for the reproduction of this article.
Références
IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt F):9-562
pubmed: 23189753
J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Oct 5;778(1-2):131-45
pubmed: 12376121
J Expo Sci Environ Epidemiol. 2017 Jan;27(1):56-63
pubmed: 26696463
Environ Toxicol Chem. 2002 Feb;21(2):260-8
pubmed: 11833793
Environ Health Perspect. 2016 Jun;124(6):713-21
pubmed: 26600562
Int J Environ Res Public Health. 2014 Apr 23;11(4):4449-527
pubmed: 24762670
Sci Rep. 2016 May 17;6:25768
pubmed: 27185567
Occup Environ Med. 2013 Feb;70(2):91-8
pubmed: 23117219
Occup Environ Med. 2016 Jun;73(6):359-67
pubmed: 27009271
Cancer Res. 2004 Mar 15;64(6):2264-9
pubmed: 15026372
Lancet Oncol. 2016 Dec;17(12):1637-1638
pubmed: 27784619
Toxicology. 2001 Aug 28;165(2-3):153-62
pubmed: 11522373
Scand J Work Environ Health. 1992 Aug;18(4):209-15
pubmed: 1411362
Int J Cancer. 2012 Dec 1;131(11):2650-9
pubmed: 22396152
Scand J Work Environ Health. 1998 Aug;24(4):255-61
pubmed: 9754856
J Natl Cancer Inst. 2018 May 1;110(5):509-516
pubmed: 29136183
Stat Med. 2011 Feb 20;30(4):377-99
pubmed: 21225900
Environ Health Perspect. 2005 Jan;113(1):49-54
pubmed: 15626647
PLoS One. 2014 Oct 22;9(10):e109332
pubmed: 25337994
Am Ind Hyg Assoc J. 1998 Mar;59(3):166-72
pubmed: 9530802
J Natl Cancer Inst Monogr. 2014 Aug;2014(48):130-44
pubmed: 25174034
Ann Occup Hyg. 2016 Jul;60(6):669-83
pubmed: 27109466
Ann Occup Hyg. 2009 Jan;53(1):69-81
pubmed: 19022871
J Occup Environ Med. 2001 Jul;43(7):641-9
pubmed: 11464396
J Environ Sci Health B. 2016;51(6):402-34
pubmed: 27015139
Cancer Causes Control. 2007 Dec;18(10):1209-26
pubmed: 17874193
Ann Epidemiol. 2015 Aug;25(8):626-636.e4
pubmed: 26066538
Am J Epidemiol. 1986 Apr;123(4):736-51
pubmed: 3953551
Occup Environ Med. 2009 May;66(5):291-8
pubmed: 19017688
Int J Cancer. 2008 Oct 1;123(7):1657-63
pubmed: 18623080
Cancer Res. 1992 May 1;52(9):2447-55
pubmed: 1568215
J Expo Sci Environ Epidemiol. 2012 Jul;22(4):409-16
pubmed: 22569205
Int J Environ Res Public Health. 2011 May;8(5):1341-57
pubmed: 21655123
Int J Epidemiol. 2005 Jun;34(3):680-7
pubmed: 15802377
Environ Pollut. 2017 Dec;231(Pt 1):319-328
pubmed: 28810201
J Expo Sci Environ Epidemiol. 2012 Nov;22(6):593-600
pubmed: 22892809
Int Arch Occup Environ Health. 2015 Jan;88(1):61-73
pubmed: 24599726
Cancer Res. 1994 May 1;54(9):2386-9
pubmed: 8162585
J Occup Environ Hyg. 2016;13(6):476-89
pubmed: 26853603
Blood. 2007 Jul 15;110(2):695-708
pubmed: 17389762
Cancer Causes Control. 2001 Aug;12(6):509-17
pubmed: 11519759
Scand J Work Environ Health. 1996 Feb;22(1):14-26
pubmed: 8685669
J Agromedicine. 2009;14(2):125-31
pubmed: 19437268
Int J Cancer. 2007;120 Suppl 12:1-39
pubmed: 17405121
Lancet Oncol. 2015 Aug;16(8):891-2
pubmed: 26111929
Toxicol Lett. 1999 Jun 30;107(1-3):219-24
pubmed: 10414799
J Natl Cancer Inst. 1987 May;78(5):899-910
pubmed: 3471999
Occup Environ Med. 2017 Jan;74(1):81
pubmed: 27852645
Environ Health Perspect. 2001 Aug;109(8):839-44
pubmed: 11564621
Environ Health Perspect. 1996 Apr;104(4):362-9
pubmed: 8732939