TET1 reprograms the epithelial ovarian cancer epigenome and reveals casein kinase 2α as a therapeutic target.
Animals
Carcinoma, Ovarian Epithelial
/ genetics
Casein Kinase II
/ genetics
Cell Line, Tumor
Cell Movement
/ physiology
Cell Proliferation
/ physiology
Cystadenocarcinoma, Serous
/ genetics
Epithelial-Mesenchymal Transition
/ genetics
Fallopian Tube Neoplasms
/ genetics
Female
Gene Expression Regulation, Neoplastic
/ genetics
Humans
Mice, Nude
Mixed Function Oxygenases
/ genetics
Ovarian Neoplasms
/ genetics
Prognosis
Proto-Oncogene Proteins
/ genetics
DNA demethylation
casein kinase-2
epigenetics
epithelial ovarian cancer
ten-eleven translocation-1
Journal
The Journal of pathology
ISSN: 1096-9896
Titre abrégé: J Pathol
Pays: England
ID NLM: 0204634
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
05
11
2018
revised:
09
02
2019
accepted:
11
03
2019
pubmed:
19
3
2019
medline:
9
4
2020
entrez:
19
3
2019
Statut:
ppublish
Résumé
Ten-eleven translocation methylcytosine dioxygenase-1, TET1, takes part in active DNA demethylation. However, our understanding of DNA demethylation in cancer biology and its clinical significance remain limited. This study showed that TET1 expression correlated with poor survival in advanced-stage epithelial ovarian carcinoma (EOC), and with cell migration, anchorage-independent growth, cancer stemness, and tumorigenicity. In particular, TET1 was highly expressed in serous tubal intraepithelial carcinoma (STIC), a currently accepted type II EOC precursor, and inversely correlated with TP53 mutations. Moreover, TET1 could demethylate the epigenome and activate multiple oncogenic pathways, including an immunomodulation network having casein kinase II subunit alpha (CK2α) as a hub. Patients with TET1
Identifiants
pubmed: 30883733
doi: 10.1002/path.5266
pmc: PMC6579655
mid: NIHMS1021449
doi:
Substances chimiques
Proto-Oncogene Proteins
0
Mixed Function Oxygenases
EC 1.-
TET1 protein, human
EC 1.-
Casein Kinase II
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
363-376Subventions
Organisme : NCI NIH HHS
ID : U01 CA200469
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211524
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA215483
Pays : United States
Informations de copyright
Copyright © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Références
J Natl Cancer Inst. 2003 Mar 19;95(6):484-6
pubmed: 12644542
Am J Pathol. 2004 May;164(5):1511-8
pubmed: 15111296
Oncogene. 2004 Oct 21;23(49):8065-77
pubmed: 15361855
Cancer Res. 2005 Apr 15;65(8):3025-9
pubmed: 15833827
Cancer Res. 2006 Jun 15;66(12):6312-8
pubmed: 16778208
Cell. 2006 Aug 25;126(4):663-76
pubmed: 16904174
Cancer Res. 2008 Jun 1;68(11):4311-20
pubmed: 18519691
Science. 2009 May 15;324(5929):930-5
pubmed: 19372391
Am J Surg Pathol. 2010 Mar;34(3):433-43
pubmed: 20154587
Methods. 2010 Nov;52(3):232-6
pubmed: 20542119
Nature. 2010 Aug 26;466(7310):1129-33
pubmed: 20639862
Am J Pathol. 2010 Sep;177(3):1087-94
pubmed: 20671266
FEBS Lett. 2011 Jan 3;585(1):104-10
pubmed: 21093442
Cancer Cell. 2011 Jan 18;19(1):17-30
pubmed: 21251613
Nature. 2011 May 19;473(7347):389-93
pubmed: 21451524
EMBO Rep. 2011 May;12(5):463-9
pubmed: 21460794
Cell. 2011 Apr 29;145(3):423-34
pubmed: 21496894
Int J Mol Sci. 2011 Jan 31;12(2):983-1008
pubmed: 21541038
Science. 2011 Sep 2;333(6047):1300-3
pubmed: 21778364
Science. 2011 Sep 2;333(6047):1303-7
pubmed: 21817016
Endocr Relat Cancer. 2012 Apr 10;19(2):197-208
pubmed: 22277193
Curr Obstet Gynecol Rep. 2012 Mar;1(1):1-9
pubmed: 22506137
Am J Surg Pathol. 2012 Dec;36(12):1826-34
pubmed: 22892598
Cell. 2012 Sep 14;150(6):1135-46
pubmed: 22980977
Cell Rep. 2012 Sep 27;2(3):568-79
pubmed: 22999938
Nucleic Acids Res. 2013 Jan;41(Database issue):D1228-33
pubmed: 23180781
Histopathology. 2013 Jan;62(1):2-30
pubmed: 23240667
Gynecol Oncol. 2013 Mar;128(3):475-82
pubmed: 23270808
Nature. 2013 Mar 21;495(7441):370-4
pubmed: 23395962
Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11994-9
pubmed: 23818607
Annu Rev Pathol. 2014;9:27-45
pubmed: 23937438
J Clin Invest. 2013 Sep;123(9):3652-8
pubmed: 23999438
Oncotarget. 2013 Dec;4(12):2366-82
pubmed: 24280306
Clin Cancer Res. 2014 Apr 15;20(8):2192-204
pubmed: 24563479
J Pathol. 2014 Jul;233(3):228-37
pubmed: 24652535
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W167-74
pubmed: 24861621
Nucleic Acids Res. 2014 Jun;42(11):6956-71
pubmed: 24875481
Bioinformatics. 2014 Dec 15;30(24):3567-74
pubmed: 25178460
Genomics. 2014 Nov;104(5):352-7
pubmed: 25179374
Stem Cells. 2015 Mar;33(3):686-98
pubmed: 25331067
Oncogene. 2015 Aug 6;34(32):4168-76
pubmed: 25362856
Mol Med Rep. 2015 Mar;11(3):2221-6
pubmed: 25405327
Gynecol Oncol. 2015 Apr;137(1):173-9
pubmed: 25677064
Nat Med. 2015 Mar;21(3):231-8
pubmed: 25686104
Biochem J. 2015 Mar 1;466(2):401-13
pubmed: 25697096
Nat Immunol. 2015 Jun;16(6):653-62
pubmed: 25867473
Carcinogenesis. 2015 Nov;36(11):1419-28
pubmed: 26363031
J Pathol. 2016 Mar;238(4):519-530
pubmed: 26415052
Oncotarget. 2015 Dec 22;6(41):43843-52
pubmed: 26549805
Nat Commun. 2015 Dec 07;6:10100
pubmed: 26639555
Oncotarget. 2016 Mar 29;7(13):15648-61
pubmed: 26871292
Am J Pathol. 2016 Apr;186(4):733-47
pubmed: 27012190
Oncotarget. 2016 May 24;7(21):31322-35
pubmed: 27121319
Sci Rep. 2016 May 26;6:26591
pubmed: 27225590
Nat Rev Genet. 2016 Aug;17(8):487-500
pubmed: 27346641
Pharmaceuticals (Basel). 2017 Jan 28;10(1):
pubmed: 28134850
Biomed Rep. 2017 Feb;6(2):127-133
pubmed: 28357063
Gynecol Oncol. 2017 Nov;147(2):408-417
pubmed: 28851501
Nat Commun. 2017 Oct 17;8(1):990
pubmed: 29042553
Nat Commun. 2017 Oct 23;8(1):1093
pubmed: 29061967
Oncotarget. 2017 Sep 23;8(49):86395-86409
pubmed: 29156803
J Natl Cancer Inst. 2018 Jul 1;110(7):692-693
pubmed: 29281080
Cancer Res. 2018 Aug 1;78(15):4126-4137
pubmed: 29891505