Distribution of atopic dermatitis lesions in United States adults.
Adolescent
Adult
Black or African American
Age Factors
Aged
Aged, 80 and over
Arm
Buttocks
Cross-Sectional Studies
Dermatitis, Atopic
/ epidemiology
Facial Dermatoses
/ epidemiology
Female
Foot Dermatoses
/ epidemiology
Genitalia
Hand Dermatoses
/ epidemiology
Hispanic or Latino
Humans
Latent Class Analysis
Leg Dermatoses
/ epidemiology
Male
Middle Aged
Prevalence
Quality of Life
Scalp Dermatoses
/ epidemiology
Surveys and Questionnaires
Torso
United States
/ epidemiology
White People
Young Adult
Journal
Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083
Titre abrégé: J Eur Acad Dermatol Venereol
Pays: England
ID NLM: 9216037
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
20
12
2018
accepted:
28
02
2019
pubmed:
19
3
2019
medline:
16
1
2020
entrez:
19
3
2019
Statut:
ppublish
Résumé
The distribution of atopic dermatitis (AD) lesions and its impact on quality of life (QOL) is not well established in the US adult population. To elucidate the distribution of AD lesions and its impact on QOL in US adults with AD. A cross-sectional, population-based study of 602 adults was performed. AD was determined using modified UK Diagnostic Criteria, and its lesional distribution was assessed. QOL was assessed using Dermatology Life Quality Index (DLQI). Latent class analysis (LCA) was used to determine distinct phenotypes of AD lesional distribution. Multivariable logistic regression was used to determine the relationship between DLQI and distinct phenotypes. The most common sites of skin lesions were reported to be the popliteal fossae, lower legs, dorsal feet and antecubital fossae. Most persons reported partial (19.0%) or complete (63.0%) symmetry of lesions on the extremities. Lesions on the trunk were significantly more common in blacks and Hispanics. Age ≥ 60 years was associated with significantly lower proportions of active lesions on the face and scalp, and significantly higher proportion of lesions on the buttocks or genitals. LCA identified 5 classes of lesional distribution: 1. lower probabilities of lesions affecting any sites; 2. Higher probability of lesions involving the anterior and posterior neck and trunk; 3. lesions involving the antecubital fossae and upper extremities; 4. lesions involving the arms, posterior hands, genitals and buttocks, and to a lesser extent face, palms and legs; 5. lesions affecting all sites. Class-2 (multivariable logistic regression; adjusted odds ratio [95% confidence interval]: 7.19 [3.21-16.07], class-3 (7.11 [3.20-15.80]), class-4 (6.90 [3.07-15.50]) and class-5 (7.92 [3.54-17.71]) were all significantly associated with higher DLQI scores compared to class 1. AD is associated with heterogeneous distribution of AD lesions, and distinct phenotypes that are associated with QOL impact.
Sections du résumé
BACKGROUND
BACKGROUND
The distribution of atopic dermatitis (AD) lesions and its impact on quality of life (QOL) is not well established in the US adult population.
OBJECTIVE
OBJECTIVE
To elucidate the distribution of AD lesions and its impact on QOL in US adults with AD.
METHODS
METHODS
A cross-sectional, population-based study of 602 adults was performed. AD was determined using modified UK Diagnostic Criteria, and its lesional distribution was assessed. QOL was assessed using Dermatology Life Quality Index (DLQI). Latent class analysis (LCA) was used to determine distinct phenotypes of AD lesional distribution. Multivariable logistic regression was used to determine the relationship between DLQI and distinct phenotypes.
RESULTS
RESULTS
The most common sites of skin lesions were reported to be the popliteal fossae, lower legs, dorsal feet and antecubital fossae. Most persons reported partial (19.0%) or complete (63.0%) symmetry of lesions on the extremities. Lesions on the trunk were significantly more common in blacks and Hispanics. Age ≥ 60 years was associated with significantly lower proportions of active lesions on the face and scalp, and significantly higher proportion of lesions on the buttocks or genitals. LCA identified 5 classes of lesional distribution: 1. lower probabilities of lesions affecting any sites; 2. Higher probability of lesions involving the anterior and posterior neck and trunk; 3. lesions involving the antecubital fossae and upper extremities; 4. lesions involving the arms, posterior hands, genitals and buttocks, and to a lesser extent face, palms and legs; 5. lesions affecting all sites. Class-2 (multivariable logistic regression; adjusted odds ratio [95% confidence interval]: 7.19 [3.21-16.07], class-3 (7.11 [3.20-15.80]), class-4 (6.90 [3.07-15.50]) and class-5 (7.92 [3.54-17.71]) were all significantly associated with higher DLQI scores compared to class 1.
CONCLUSION
CONCLUSIONS
AD is associated with heterogeneous distribution of AD lesions, and distinct phenotypes that are associated with QOL impact.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1341-1348Informations de copyright
© 2019 European Academy of Dermatology and Venereology.