Biochemical Urine Testing of Adherence to Cardiovascular Medications Reveals High Rates of Nonadherence in People Attending Their Annual Review for Type 2 Diabetes.
Adult
Aged
Antihypertensive Agents
/ therapeutic use
Chromatography, Liquid
Diabetes Mellitus, Type 2
/ drug therapy
Drug Utilization Review
/ methods
Female
Humans
Hypoglycemic Agents
/ therapeutic use
Male
Medication Adherence
/ statistics & numerical data
Middle Aged
Primary Health Care
/ standards
Tandem Mass Spectrometry
United Kingdom
/ epidemiology
Urinalysis
/ methods
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
07
07
2018
accepted:
18
02
2019
pubmed:
20
3
2019
medline:
26
3
2020
entrez:
20
3
2019
Statut:
ppublish
Résumé
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a new method to objectively and robustly detect nonadherence. We applied this technique to study nonadherence to cardiovascular medications in people with type 2 diabetes (T2DM). Routine urine samples, received at the time of the annual diabetes review from 228 people with T2DM in primary care, were assessed for adherence by LC-MS/MS. A total of 28.1% patients ( This unique study shows that routine urine samples can be used for adherence testing screening by LC-MS/MS and has demonstrated high nonadherence rates especially to statins in people with T2DM. Future intervention studies using LC-MS/MS as a diagnostic/therapeutic tool may help to improve clinical outcomes.
Identifiants
pubmed: 30885952
pii: dc18-1453
doi: 10.2337/dc18-1453
doi:
Substances chimiques
Antihypertensive Agents
0
Hypoglycemic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1132-1135Informations de copyright
© 2019 by the American Diabetes Association.