Electroconvulsive stimulation differentially affects [
5HT receptors
[C]MDL100907
electroconvulsive stimulation
minipig
positron emission tomography
serotonin
Journal
Journal of psychopharmacology (Oxford, England)
ISSN: 1461-7285
Titre abrégé: J Psychopharmacol
Pays: United States
ID NLM: 8907828
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
pubmed:
20
3
2019
medline:
24
6
2020
entrez:
20
3
2019
Statut:
ppublish
Résumé
Electroconvulsive therapy is an effective therapy of depression. We hypothesized that the beneficial effects are mediated partly by decreased serotonin receptor availability in the cortex. We used positron emission tomography with the serotonin 5HT Seven Göttingen minipigs were deeply anaesthetized and imaged at baseline before the onset of ECS, and at 1-2 and 8-10 days after the end of a clinical course of ECS, consisting of 10 sessions over 3.5 weeks, and post-ECS values were compared to baseline. One additional minipig was anaesthetized over 10 sessions without ECS, as a control. We analysed images with the Ichise model for binding in cortex and hippocampus, followed by whole-brain analysis by statistical non-parametric mapping. We found significantly increased binding potential of [ With ECS, minipigs, unlike primates but like rodents, have higher availability at cortical and hippocampal 5HT
Sections du résumé
BACKGROUND
Electroconvulsive therapy is an effective therapy of depression. We hypothesized that the beneficial effects are mediated partly by decreased serotonin receptor availability in the cortex.
AIMS
We used positron emission tomography with the serotonin 5HT
METHODS
Seven Göttingen minipigs were deeply anaesthetized and imaged at baseline before the onset of ECS, and at 1-2 and 8-10 days after the end of a clinical course of ECS, consisting of 10 sessions over 3.5 weeks, and post-ECS values were compared to baseline. One additional minipig was anaesthetized over 10 sessions without ECS, as a control. We analysed images with the Ichise model for binding in cortex and hippocampus, followed by whole-brain analysis by statistical non-parametric mapping.
RESULTS
We found significantly increased binding potential of [
CONCLUSIONS
With ECS, minipigs, unlike primates but like rodents, have higher availability at cortical and hippocampal 5HT
Identifiants
pubmed: 30887871
doi: 10.1177/0269881119836212
doi:
Substances chimiques
Receptor, Serotonin, 5-HT2C
0
Serotonin
333DO1RDJY
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM