Accelerated thymopoiesis and improved T-cell responses in HLA-A2/-DR2 transgenic BRGS-based human immune system mice.
Animal models
Humanized mice
Lymphocyte development
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
08
11
2018
revised:
04
02
2019
accepted:
04
03
2019
pubmed:
20
3
2019
medline:
28
5
2020
entrez:
20
3
2019
Statut:
ppublish
Résumé
Human immune system (HIS) mouse models provide a robust in vivo platform to study human immunity. Nevertheless, the signals that guide human lymphocyte differentiation in HIS mice remain poorly understood. Here, we have developed a novel Balb/c Rag2
Identifiants
pubmed: 30888052
doi: 10.1002/eji.201848001
doi:
Substances chimiques
HLA-A2 Antigen
0
HLA-DR2 Antigen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
954-965Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.