Relationships between brain perfusion and early recanalization after intravenous thrombolysis for acute stroke with large vessel occlusion.
Cerebral perfusion
ischemic stroke
magnetic resonance imaging
thrombectomy
thrombolysis
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
pubmed:
21
3
2019
medline:
22
9
2020
entrez:
21
3
2019
Statut:
ppublish
Résumé
In large vessel occlusion (LVO) stroke, it is unclear whether severity of ischemia is involved in early post-thrombolysis recanalization over and above thrombus site and length. Here we assessed the relationships between perfusion parameters and early recanalization following intravenous thrombolysis administration in LVO patients. From a multicenter registry, we identified 218 thrombolysed LVO patients referred for thrombectomy with both (i) pre-thrombolysis MRI, including diffusion-weighted imaging (DWI), T2*-imaging, MR-angiography and dynamic susceptibility-contrast perfusion-weighted imaging (PWI); and (ii) evaluation of recanalization on first angiographic run or non-invasive imaging ≤ 3 h from thrombolysis start. Infarct core volume on DWI, PWI-DWI mismatch volume and hypoperfusion intensity ratio (HIR; defined as Tmax ≥ 10 s volume/ Tmax ≥ 6 s volume, low HIR indicating milder hypoperfusion) were determined using a commercially available software. Early recanalization occurred in 34 (16%) patients, and multivariable analysis was associated with lower HIR (
Identifiants
pubmed: 30890074
doi: 10.1177/0271678X19836288
pmc: PMC7026851
doi:
Types de publication
Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
667-677Références
Stroke. 2018 Jan;49(1):232-235
pubmed: 29212743
Rev Neurol (Paris). 2017 Nov;173(9):584-589
pubmed: 29037436
AJNR Am J Neuroradiol. 2013 Jan;34(1):107-14
pubmed: 22766675
PLoS One. 2013 Oct 11;8(10):e76727
pubmed: 24146915
Neurology. 2008 Nov 25;71(22):1804-11
pubmed: 19029520
Brain. 2015 Jul;138(Pt 7):1919-31
pubmed: 25808369
Eur J Neurol. 2017 Aug;24(8):1016-1021
pubmed: 28649759
Eur J Neurol. 2014 Nov;21(11):1406-10
pubmed: 25040586
Stroke. 2018 Mar;49(3):768-771
pubmed: 29367336
Stroke. 2016 Sep;47(9):2409-12
pubmed: 27462117
Int J Stroke. 2015 Apr;10(3):348-53
pubmed: 23802548
N Engl J Med. 2018 Feb 22;378(8):708-718
pubmed: 29364767
AJNR Am J Neuroradiol. 2014 Dec;35(12):2265-72
pubmed: 25059699
Lancet Neurol. 2019 Jan;18(1):46-55
pubmed: 30413385
Stroke. 2017 Dec;48(12):3282-3288
pubmed: 29114095
Front Neurol. 2018 Jul 24;9:586
pubmed: 30087652
Stroke. 2003 Feb;34(2):458-63
pubmed: 12574560
Stroke. 2017 Oct;48(10):2912-2918
pubmed: 28887391
Stroke. 2012 Nov;43(11):2974-9
pubmed: 22961960
Stroke. 2015 Apr;46(4):968-75
pubmed: 25700286
Eur J Neurol. 2013 May;20(5):795-802
pubmed: 23278976
J Neurol Neurosurg Psychiatry. 2008 Jun;79(6):625-9
pubmed: 18077482
Stroke. 2018 Aug;49(8):1805-1808
pubmed: 29946011
Int J Stroke. 2017 Aug;12(6):606-614
pubmed: 28534706
Stroke. 2016 Feb;47(2):531-4
pubmed: 26658445
Stroke. 2015 Oct;46(10):2800-7
pubmed: 26306754
Stroke. 2018 Aug;49(8):1924-1932
pubmed: 29986932
JAMA. 2018 Sep 11;320(10):1017-1026
pubmed: 30208455
N Engl J Med. 2018 Jan 4;378(1):11-21
pubmed: 29129157
Stroke. 2007 Mar;38(3):967-73
pubmed: 17272772
Sci Rep. 2016 Jun 14;6:27880
pubmed: 27296511
Stroke. 2018 Mar;49(3):e46-e110
pubmed: 29367334
Stroke. 2014 Apr;45(4):1018-23
pubmed: 24595591
Ann Neurol. 2017 Jun;81(6):849-856
pubmed: 28486789
Stroke. 2011 Nov;42(11):3150-5
pubmed: 21868738
Lancet Neurol. 2012 Oct;11(10):860-7
pubmed: 22954705
Stroke. 2018 Jun;49(6):1426-1433
pubmed: 29739914
Ann Neurol. 2018 Jan;83(1):178-185
pubmed: 29314208
Stroke. 2015 Nov;46(11):3302-9
pubmed: 26451027
Stroke. 2013 Sep;44(9):2650-63
pubmed: 23920012
Stroke. 2014 Jun;45(6):1727-32
pubmed: 24876260
Int J Stroke. 2018 Aug;13(6):554-567
pubmed: 29543140
Stroke. 2016 Apr;47(4):1018-22
pubmed: 26917566
Ann Neurol. 2018 Oct;84(4):616-620
pubmed: 30168180
Ann Neurol. 2016 Aug;80(2):286-93
pubmed: 27352245
Stroke. 2018 Dec;49(12):2975–2982
pubmed: 30730694