Efficacy of Valganciclovir Treatment Depends on the Severity of Hearing Dysfunction in Symptomatic Infants with Congenital Cytomegalovirus Infection.
auditory brainstem response
congenital cytomegalovirus infection
hearing dysfunction
severity
valganciclovir
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Mar 2019
19 Mar 2019
Historique:
received:
30
01
2019
revised:
12
03
2019
accepted:
15
03
2019
entrez:
22
3
2019
pubmed:
22
3
2019
medline:
11
7
2019
Statut:
epublish
Résumé
Although earlier studies have shown that antiviral treatment regimens using valganciclovir (VGCV) improved hearing function in some infants with congenital cytomegalovirus (CMV) infection; its efficacy on the severity of hearing dysfunction is unclear. We conducted a prospective study among 26 infants with congenital CMV infections from 2009 to 2018. Oral VGCV (32 mg/kg/day) was administered for 6 weeks (November 2009 to June 2015;
Identifiants
pubmed: 30893926
pii: ijms20061388
doi: 10.3390/ijms20061388
pmc: PMC6471816
pii:
doi:
Substances chimiques
Valganciclovir
GCU97FKN3R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Health, Labour and Welfare of Japan
ID : H23-Jisedai-Ippan-001, H25-Jisedai-Shitei-003, and H30-Kansei-Shitei-002
Organisme : Japan Agency for Medical Research and Development, AMED
ID : 15gk0110003h0103 and 16gk0110021h0001
Organisme : Kawano Masanori Memorial Foundation for Promotion of Pediatrics
ID : 2018
Références
J Pediatr. 2003 Jul;143(1):16-25
pubmed: 12915819
Pediatrics. 2006 Jan;117(1):e76-83
pubmed: 16326692
N Engl J Med. 2006 May 18;354(20):2151-64
pubmed: 16707752
Pediatr Infect Dis J. 2009 Jul;28(7):588-92
pubmed: 19478688
Eur J Clin Microbiol Infect Dis. 2009 Dec;28(12):1465-70
pubmed: 19763643
Eur J Pediatr. 2010 Sep;169(9):1061-7
pubmed: 20232081
BMJ Open. 2011 Jul 29;1(1):e000118
pubmed: 22021766
Acta Neuropathol. 2011 Dec;122(6):763-74
pubmed: 22033878
Brain Dev. 2014 Jan;36(1):10-5
pubmed: 23312952
Pediatr Int. 2014 Oct;56(5):702-8
pubmed: 24617834
J Perinat Med. 2015 Mar;43(2):239-43
pubmed: 24968403
Pediatrics. 2014 Nov;134(5):972-82
pubmed: 25349318
N Engl J Med. 2015 Mar 5;372(10):933-43
pubmed: 25738669
Brain Dev. 2016 Feb;38(2):209-16
pubmed: 26282917
Arch Dis Child. 2016 May;101(5):433-8
pubmed: 26826174
Eur Ann Otorhinolaryngol Head Neck Dis. 2016 Dec;133(6):413-418
pubmed: 27067701
Lancet Infect Dis. 2017 Jun;17(6):e177-e188
pubmed: 28291720
J Infect Dis. 2019 Apr 16;219(9):1398-1406
pubmed: 30535363
J Infect Dis. 1997 May;175(5):1080-6
pubmed: 9129069