Activation of innate immunity by mitochondrial dsRNA in mouse cells lacking p53 protein.

Adaptor Proteins, Signal Transducing Adenosine Deaminase / deficiency Animals Carrier Proteins / genetics DEAD Box Protein 58 / genetics Embryo, Mammalian Endoribonucleases / genetics Fibroblasts / cytology Immunity, Innate / genetics Interferon Regulatory Factor-7 / genetics Interferon-Induced Helicase, IFIH1 / genetics Intracellular Signaling Peptides and Proteins Mice Mice, Inbred C57BL Mice, Knockout Proteins / genetics RNA, Double-Stranded / genetics RNA, Mitochondrial / genetics RNA-Binding Proteins Transcription, Genetic Transfection Tumor Suppressor Protein p53 / deficiency
RNase L innate immunity mitochondrial dsRNA p53

Journal

RNA (New York, N.Y.)
ISSN: 1469-9001
Titre abrégé: RNA
Pays: United States
ID NLM: 9509184

Informations de publication

Date de publication:
06 2019
Historique:
received: 26 11 2018
accepted: 16 03 2019
pubmed: 22 3 2019
medline: 14 6 2019
entrez: 22 3 2019
Statut: ppublish

Résumé

Viral and cellular double-stranded RNA (dsRNA) is recognized by cytosolic innate immune sensors, including RIG-I-like receptors. Some cytoplasmic dsRNA is commonly present in cells, and one source is mitochondrial dsRNA, which results from bidirectional transcription of mitochondrial DNA (mtDNA). Here we demonstrate that

Identifiants

DOI: 10.1261/rna.069625.118 PMID: 30894411 PMC: PMC6521600
pubmed: 30894411
pii: rna.069625.118
doi: 10.1261/rna.069625.118
pmc: PMC6521600
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
Carrier Proteins 0
Ifit1 protein, mouse 0
Ifit3 protein, mouse 0
Interferon Regulatory Factor-7 0
Intracellular Signaling Peptides and Proteins 0
Irf7 protein, mouse 0
Proteins 0
RNA, Double-Stranded 0
RNA, Mitochondrial 0
RNA-Binding Proteins 0
Trp53 protein, mouse 0
Tumor Suppressor Protein p53 0
Endoribonucleases EC 3.1.-
2-5A-dependent ribonuclease EC 3.1.26.-
ADAR1 protein, mouse EC 3.5.4.4
Adenosine Deaminase EC 3.5.4.4
Ddx58 protein, mouse EC 3.6.1.-
Ifih1 protein, mouse EC 3.6.1.-
DEAD Box Protein 58 EC 3.6.4.13
Interferon-Induced Helicase, IFIH1 EC 3.6.4.13

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

713-726

Informations de copyright

© 2019 Wiatrek et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

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Auteurs

Dagmara M Wiatrek (DM)

CEITEC Masaryk University, 625 00 Brno, Czech Republic.

Maria E Candela (ME)

CEITEC Masaryk University, 625 00 Brno, Czech Republic.

Jiří Sedmík (J)

CEITEC Masaryk University, 625 00 Brno, Czech Republic.

Jan Oppelt (J)

CEITEC Masaryk University, 625 00 Brno, Czech Republic.
National Centre for Biomolecular Research, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic.

Liam P Keegan (LP)

CEITEC Masaryk University, 625 00 Brno, Czech Republic.

Mary A O'Connell (MA)

CEITEC Masaryk University, 625 00 Brno, Czech Republic.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Aminohydrolases › Nucleoside deaminases › Adenosine deaminase › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Eucaryotes › Animaux › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › RNA helicases › DEAD-box RNA helicases › Protéine-58 à domaine DEAD › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Structures de l'embryon › Embryon de mammifère › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Ribonucléases › Endoribonucleases › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de régulation d'interféron › Facteur-7 de régulation d'interféron › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de restriction antiviraux › Hélicase IFIH1 inductrice de l'interféron › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › ARN double brin › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN mitochondrial › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Transfection › Activation of innate immunity by mitochondrial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › Activation of innate immunity by mitochondrial...