Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Animals
Cryptosporidiosis
/ drug therapy
Cryptosporidium parvum
/ enzymology
Disease Models, Animal
Enzyme Inhibitors
/ chemistry
Humans
Lysine-tRNA Ligase
/ antagonists & inhibitors
Malaria, Falciparum
/ drug therapy
Mice, SCID
Plasmodium falciparum
/ enzymology
Protozoan Proteins
/ antagonists & inhibitors
cryptosporidiosis
malaria
tRNA synthetase
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
02 04 2019
02 04 2019
Historique:
pubmed:
22
3
2019
medline:
22
5
2019
entrez:
22
3
2019
Statut:
ppublish
Résumé
Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of high priority; however, there are few chemically validated targets. The natural product cladosporin is active against blood- and liver-stage
Identifiants
pubmed: 30894487
pii: 1814685116
doi: 10.1073/pnas.1814685116
pmc: PMC6452685
doi:
Substances chimiques
Enzyme Inhibitors
0
Protozoan Proteins
0
Lysine-tRNA Ligase
EC 6.1.1.6
Banques de données
PDB
['6AGT', '6HCU', '6HCV', '5ELN', '5ELO', '6HCW']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
7015-7020Subventions
Organisme : NCRR NIH HHS
ID : P20 RR021905
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI130807
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI112427
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI090141
Pays : United States
Organisme : Wellcome Trust
ID : 203134/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203134
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R21 AI123690
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI103058
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM125498
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM118228
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201200025C
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 094090
Pays : United Kingdom
Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Conflict of interest statement: A patent relating to this work has been filed (PCT/GB2017/051809). F.-J.G. and L.M.S. are employees of GlaxoSmithKline and own shares of the company. M.B.J.-D. and I.A.-B. have shares in The Art of Discovery. Editor D.E.G. is a recent coauthor with two authors of this paper. He published a research article with M.A. in 2015. With E.A.W. he published two research articles in 2016, one research article in 2018, and coauthored a research article forthcoming in 2019. D.E.G. is a coinvestigator with E.A.W. on a 2012–2019 grant.
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