The prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5-azacytidine: Results from the Hellenic 5-azacytidine registry.


Journal

Cancer medicine
ISSN: 2045-7634
Titre abrégé: Cancer Med
Pays: United States
ID NLM: 101595310

Informations de publication

Date de publication:
05 2019
Historique:
received: 08 09 2018
revised: 28 12 2018
accepted: 12 02 2019
pubmed: 22 3 2019
medline: 1 7 2020
entrez: 22 3 2019
Statut: ppublish

Résumé

In patients with myelodysplastic syndrome (MDS), the prognostic significance of chromosome 17 abnormalities has not yet been fully elucidated, except for isochromosome 17q that has been characterized as an intermediate risk abnormality in the Revised International Prognostic Scoring System (IPSS-R). To further characterize the prognostic significance of chromosome 17 abnormalities we analyzed the hematologic and prognostic characteristics of 548 adult patients with MDS treated with 5-azacytidine through the Hellenic 5-azacytidine registry and found 32 patients with a chromosome 17 abnormality (6 with i[17q], 15 with -17, 3 with add[17p] and the rest with other rarer abnormalities, mostly translocations). The presence of a chromosome 17 abnormality was correlated with poor prognostic features (high IPSS, IPSS-R, and WPSS scores) and a low overall survival rate (15.7 vs 36.4 months for patients without chromosome 17 abnormalities, Kaplan-Meier, Log Rank P < 0.00001), but these results were confounded by the fact that most (92.3%) of the cases with a chromosome 17 abnormality (with the exception of i(17q) that was found in all cases as an isolated abnormality) were found in the context of a complex karyotype. Nevertheless, one should not ignore the contribution of chromosome 17 abnormalities to the prognostic significance of a complex karyotype since 33.8% of complex karyotypes encompassed a chromosome 17 abnormality.

Identifiants

pubmed: 30897290
doi: 10.1002/cam4.2090
pmc: PMC6536924
doi:

Substances chimiques

Antimetabolites, Antineoplastic 0
Azacitidine M801H13NRU

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2056-2063

Informations de copyright

© 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

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Auteurs

Panagiotis Diamantopoulos (P)

Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Dafni Koumbi (D)

Institute of Nuclear and Radiological Sciences, National Center for Scientific Research Demokritos, Athens, Greece.

Ioannis Kotsianidis (I)

Department of Hematology, University Hospital of Alexandroupolis, Alexandroupoli, Greece.

Vasiliki Pappa (V)

Haematology Division, Second Department of Internal Medicine, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Argiris Symeonidis (A)

Department of Internal Medicine, University Hospital of Patras, Rio, Greece.

Athanasios Galanopoulos (A)

Department of Clinical Hematology, 'G. Gennimatas' District General Hospital, Athens, Greece.

Panagiotis Zikos (P)

Department of Hematology, 'St Andrew' General Hospital, Patras, Greece.

Helen A Papadaki (HA)

Haematology Laboratory, School of Medicine, University of Crete, Greece.

Panayiotis Panayiotidis (P)

First Propedeutic Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Maria Dimou (M)

First Propedeutic Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Eleftheria Hatzimichael (E)

Department of Haematology, University of Ioannina, Ioannina, Greece.

George Vassilopoulos (G)

Department of Hematology, Larissa University Hospital, University of Thessalia, Larissa, Greece.

Susan Delimpasis (S)

Department of Hematology, Evangelismos Hospital, Athens, Greece.

Despoina Mparmparousi (D)

Hematology Laboratory, Alexandra General Hospital, Athens, Greece.

Sotirios Papageorgiou (S)

Haematology Division, Second Department of Internal Medicine, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Eleni Variami (E)

Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Marie-Christine Kyrtsonis (MC)

First Propedeutic Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Aekaterini Megalakaki (A)

Department of Hematology, Metaxa Anticancer Hospital, Piraeus, Greece.

Maria Kotsopoulou (M)

Department of Hematology, Metaxa Anticancer Hospital, Piraeus, Greece.

Panagiotis Repousis (P)

Department of Hematology, Metaxa Anticancer Hospital, Piraeus, Greece.

Ioannis Adamopoulos (I)

General Hospital of Kalamata, Greece.

Flora Kontopidou (F)

Second Department of Internal Medicine, National and Kapodistrian University of Athens, Hippokratio General Hospital, Athens, Greece.

Dimitrios Christoulas (D)

Department of Hematology, 251 General Air-Force Hospital, Athens, Greece.

Alexandra Kourakli (A)

Department of Internal Medicine, University Hospital of Patras, Rio, Greece.

Dimitrios Tsokanas (D)

Department of Clinical Hematology, 'G. Gennimatas' District General Hospital, Athens, Greece.

Menelaos Konstantinos Papoutselis (M)

Department of Hematology, University Hospital of Alexandroupolis, Alexandroupoli, Greece.

Georgios Kyriakakis (G)

Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Nora-Athina Viniou (NA)

Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

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