A Snapshot on the Cis Chromatin Response to DNA Double-Strand Breaks.
chromatin modifications
double-strand breaks
repair histone code
Journal
Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
21
12
2018
revised:
15
02
2019
accepted:
23
02
2019
pubmed:
23
3
2019
medline:
1
7
2020
entrez:
23
3
2019
Statut:
ppublish
Résumé
In eukaryotes, detection and repair of DNA double-strand breaks (DSBs) operate within chromatin, an incredibly complex structure that tightly packages and regulates DNA metabolism. Chromatin participates in the repair of these lesions at multiple steps, from detection to genomic sequence recovery and chromatin is itself extensively modified during the repair process. In recent years, new methodologies and dedicated techniques have expanded the experimental toolbox, opening up a new era granting the high-resolution analysis of chromatin modifications at annotated DSBs in a genome-wide manner. A complex picture is starting to emerge whereby chromatin is altered at various scales around DSBs, in a manner that relates to the repair pathway used, hence defining a 'repair histone code'. Here, we review the recent advances regarding our knowledge of the chromatin landscape induced in cis around DSBs, with an emphasis on histone post-translational modifications and histone variants.
Identifiants
pubmed: 30898334
pii: S0168-9525(19)30032-0
doi: 10.1016/j.tig.2019.02.003
pii:
doi:
Substances chimiques
Chromatin
0
Heterochromatin
0
Histones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
330-345Subventions
Organisme : European Research Council
ID : 647344
Pays : International
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.