Nonasaccharide Inhibits Intrinsic Factor Xase Complex by Binding to Factor IXa and Disrupting Factor IXa-Factor VIIIa Interactions.

Animals Carbon Dioxide / chemistry Cysteine Endopeptidases / metabolism Disease Models, Animal Factor IXa / metabolism Factor X / metabolism Heparin, Low-Molecular-Weight / therapeutic use Humans Kinetics Magnetic Resonance Spectroscopy Neoplasm Proteins / antagonists & inhibitors Oligosaccharides / chemistry Protein Binding Rats Structure-Activity Relationship Venous Thrombosis / drug therapy

Journal

Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063

Informations de publication

Date de publication:
May 2019
Historique:
pubmed: 23 3 2019
medline: 10 1 2020
entrez: 23 3 2019
Statut: ppublish

Résumé

A nonasaccharide (FG9) derived from natural fucosylated glycosaminoglycan (FG) is identified as a selective intrinsic factor Xase complex (FIXa-FVIIIa-Ca

Identifiants

DOI: 10.1055/s-0039-1681047 PMID: 30900221
pubmed: 30900221
doi: 10.1055/s-0039-1681047
doi:

Substances chimiques

Heparin, Low-Molecular-Weight 0
Neoplasm Proteins 0
Oligosaccharides 0
Carbon Dioxide 142M471B3J
carboxyl radical 14485-07-5
Factor X 9001-29-0
Factor IXa EC 3.4.21.22
Cysteine Endopeptidases EC 3.4.22.-
cancer procoagulant EC 3.4.22.26

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

705-715

Informations de copyright

Georg Thieme Verlag KG Stuttgart · New York.

Déclaration de conflit d'intérêts

None declared.

Auteurs

Chuang Xiao (C)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China.

Longyan Zhao (L)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.

Na Gao (N)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.

Mingyi Wu (M)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.

Jinhua Zhao (J)

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Dioxyde de carbone › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Cysteine endopeptidases › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Facteur IX › Facteur IXa › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Facteur X › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Glucides › Polyosides › Glycosaminoglycanes › Héparine › Héparine bas poids moléculaire › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Glucides › Polyosides › Oligosaccharides › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Nonasaccharide Inhibits Intrinsic Factor Xase...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thrombose › Thrombose veineuse › Nonasaccharide Inhibits Intrinsic Factor Xase...