Novel two-chain fatty acid-based lipids for development of vancomycin pH-responsive liposomes against
A549 Cells
Animals
Anti-Bacterial Agents
/ chemistry
Cell Line, Tumor
Drug Liberation
/ drug effects
Fatty Acids
/ chemistry
Hep G2 Cells
Humans
Hydrogen-Ion Concentration
Lipids
/ chemistry
Liposomes
/ chemistry
MCF-7 Cells
Male
Methicillin-Resistant Staphylococcus aureus
/ drug effects
Mice
Mice, Inbred BALB C
Microbial Sensitivity Tests
Staphylococcal Infections
/ drug therapy
Vancomycin
/ chemistry
MRSA
Vancomycin
fatty acid-based lipids
pH-responsive liposome
targeted drug delivery
Journal
Journal of drug targeting
ISSN: 1029-2330
Titre abrégé: J Drug Target
Pays: England
ID NLM: 9312476
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
pubmed:
23
3
2019
medline:
19
8
2020
entrez:
23
3
2019
Statut:
ppublish
Résumé
The development of bacterial resistance against antibiotics is attributed to poor localisation of lethal antibiotic dose at the infection site. This study reports on the synthesis and use of novel two-chain fatty acid-based lipids (FAL) containing amino acid head groups in the formulation of pH-responsive liposomes for the targeted delivery of vancomycin (VAN). The formulated liposomes were characterised for their size, polydispersity index (PDI), surface charge and morphology. The drug-loading capacity, drug release, cell viability, and
Identifiants
pubmed: 30901236
doi: 10.1080/1061186X.2019.1599380
doi:
Substances chimiques
Anti-Bacterial Agents
0
Fatty Acids
0
Lipids
0
Liposomes
0
Vancomycin
6Q205EH1VU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM