Differential Regulation of Type I and Type III Interferon Signaling.
Interferon
JAK-STAT
interferon signaling
signal transduction
type I IFN
type III IFN
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Mar 2019
21 Mar 2019
Historique:
received:
21
02
2019
revised:
15
03
2019
accepted:
18
03
2019
entrez:
24
3
2019
pubmed:
25
3
2019
medline:
17
7
2019
Statut:
epublish
Résumé
Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by directly inducing anti-pathogen molecular countermeasures. There are three classes of IFNs: type I, type II and type III. While type II IFN is specific for immune cells, type I and III IFNs are expressed by both immune and tissue specific cells. Unlike type I IFNs, type III IFNs have a unique tropism where their signaling and functions are mostly restricted to epithelial cells. As such, this class of IFN has recently emerged as a key player in mucosal immunity. Since the discovery of type III IFNs, the last 15 years of research in the IFN field has focused on understanding whether the induction, the signaling and the function of these powerful cytokines are regulated differently compared to type I IFN-mediated immune response. This review will cover the current state of the knowledge of the similarities and differences in the signaling pathways emanating from type I and type III IFN stimulation.
Identifiants
pubmed: 30901970
pii: ijms20061445
doi: 10.3390/ijms20061445
pmc: PMC6471306
pii:
doi:
Substances chimiques
Biomarkers
0
Interferon Regulatory Factors
0
Interferon Type I
0
STAT Transcription Factors
0
Interferons
9008-11-1
Janus Kinases
EC 2.7.10.2
Interferon Lambda
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 240245660
Organisme : FP7 People: Marie-Curie Actions
ID : FP7-PEOPLE-2012-CIG
Organisme : Chica and Heinz Schaller Foundation
ID : n/a
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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