Leveraging Implementation Science to Address Health Disparities in Genomic Medicine: Examples from the Field.
Best Practices
Genetic Disorders
Genomics
Health Disparities
Health Equity
Implementation Science
Population Health
Public Health
T4 Translation
Translational Research
Journal
Ethnicity & disease
ISSN: 1945-0826
Titre abrégé: Ethn Dis
Pays: United States
ID NLM: 9109034
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
26
3
2019
pubmed:
25
3
2019
medline:
1
7
2020
Statut:
epublish
Résumé
The integration of genomic data into screening, prevention, diagnosis, and treatment for clinical and public health practices has been slow and challenging. Implementation science can be applied in tackling the barriers and challenges as well as exploring opportunities and best practices for integrating genomic data into routine clinical and public health practice.In this article, we define the state of disparities in genomic medicine and focus predominantly on late-stage research findings. We use case studies from genetic testing for cardiovascular diseases (familial hypercholesterolemia) and cancer (Lynch syndrome and hereditary breast and ovarian cancer syndrome) in high-risk populations to consider current disparities and related barriers in turning genomic advances into population health impact to advance health equity. Finally, we address how implementation science can address these translational barriers and we discuss the strategic importance of collaborative multi-stakeholder approaches that engage public health agencies, professional societies, academic health and research centers, community clinics, and patients and their families to work collectively to improve population health and reduce or eliminate health inequities.
Identifiants
pubmed: 30906168
doi: 10.18865/ed.29.S1.187
pii: ed.29.S1.187
pmc: PMC6428174
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
187-192Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR002490
Pays : United States
Déclaration de conflit d'intérêts
Competing Interests: None declared.
Références
Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):361-5
pubmed: 15006909
JAMA. 2005 Apr 13;293(14):1729-36
pubmed: 15827311
Prev Med. 2006 Jan;42(1):51-9
pubmed: 16297974
Am J Med Genet A. 2006 Apr 15;140(8):813-26
pubmed: 16523520
Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):618-23
pubmed: 16614100
J Clin Oncol. 2006 May 10;24(14):2197-203
pubmed: 16682739
Community Genet. 2008;11(1):36-42
pubmed: 18196916
J Genet Couns. 2009 Feb;18(1):60-71
pubmed: 18686019
Genet Med. 2009 Jan;11(1):35-41
pubmed: 19125126
Implement Sci. 2009 Aug 07;4:50
pubmed: 19664226
Genet Med. 2009 Sep;11(9):655-62
pubmed: 19752639
Am J Surg. 2009 Oct;198(4):562-5
pubmed: 19800469
Public Health Genomics. 2011;14(1):1-8
pubmed: 20051673
Genet Med. 2011 Apr;13(4):349-55
pubmed: 21358336
Public Health Genomics. 2011;14(6):356-70
pubmed: 21540561
J Clin Lipidol. 2011 Jun;5(3 Suppl):S1-8
pubmed: 21600525
J Genet Couns. 2011 Dec;20(6):625-38
pubmed: 21691939
J Natl Cancer Inst Monogr. 2012 May;2012(44):112-20
pubmed: 22623603
Psychooncology. 2013 Jul;22(7):1594-604
pubmed: 22987526
Genet Med. 2013 Apr;15(4):258-67
pubmed: 23306799
Transl Behav Med. 2013 Jun 1;3(2):200-210
pubmed: 23750180
Eur J Hum Genet. 2014 Jul;22(7):866-74
pubmed: 24253862
Prev Chronic Dis. 2014 Jul 24;11:E127
pubmed: 25058673
Am J Hypertens. 2015 Jun;28(6):699-716
pubmed: 25498998
Implement Sci. 2014 Dec 11;9:181
pubmed: 25500097
Glob Heart. 2015 Mar;10(1):1-2
pubmed: 25754560
Breast Cancer Res Treat. 2015 May;151(1):169-76
pubmed: 25868867
Implement Sci. 2015 Feb 12;10:21
pubmed: 25889199
Implement Sci. 2015 Apr 21;10:53
pubmed: 25895742
Am J Public Health. 2015 Jul;105 Suppl 3:S395-402
pubmed: 25905828
BMC Psychol. 2015 Sep 16;3:32
pubmed: 26376626
Implement Sci. 2015 Nov 04;10:155
pubmed: 26537706
JAMA. 2016 May 10;315(18):1941-2
pubmed: 27163980
J Am Coll Cardiol. 2016 Aug 2;68(5):517-524
pubmed: 27470459
Genet Med. 2017 Aug;19(8):858-863
pubmed: 28079898
BMC Public Health. 2017 May 25;17(1):503
pubmed: 28545429
Circ J. 2017 Dec 25;82(1):218-223
pubmed: 28701632
Med Care. 2017 Sep;55 Suppl 9 Suppl 2:S16-S23
pubmed: 28806362
Atherosclerosis. 2017 Dec;267:19-26
pubmed: 29080546
Implement Sci. 2017 Nov 3;12(1):125
pubmed: 29100551
Genet Med. 2018 Sep;20(9):995-1003
pubmed: 29300382
J Community Genet. 2019 Jan;10(1):51-60
pubmed: 29508367
JAMA Oncol. 2018 Jun 1;4(6):876-879
pubmed: 29710084
Health Aff (Millwood). 2018 May;37(5):801-808
pubmed: 29733730
Health Aff (Millwood). 2018 May;37(5):780-785
pubmed: 29733732
Gynecol Oncol. 2018 Oct;151(1):153-158
pubmed: 30077346