Immobilizing argatroban and mPEG-NH
Adult
Anticoagulants
/ chemistry
Arginine
/ analogs & derivatives
Blood
Blood Coagulation
/ drug effects
Coated Materials, Biocompatible
/ chemistry
Female
Fibrinolytic Agents
/ chemistry
Humans
Indoles
/ chemistry
Membranes, Artificial
Pipecolic Acids
/ chemistry
Platelet Adhesiveness
/ drug effects
Polyethylene Glycols
/ chemistry
Polymers
/ chemistry
Sulfonamides
Sulfones
/ chemistry
Surface Properties
Polyethersulfone dialyzer membrane
antithrombotic
argatroban
methoxy polyethylene glycol amine
polydopamine
Journal
Journal of biomaterials science. Polymer edition
ISSN: 1568-5624
Titre abrégé: J Biomater Sci Polym Ed
Pays: England
ID NLM: 9007393
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
pubmed:
26
3
2019
medline:
24
3
2020
entrez:
26
3
2019
Statut:
ppublish
Résumé
Systemic anticoagulation is not suitable for hemodialysis (HD) patients with a high risk of bleeding in the clinic. An HD membrane that provides a localized anticoagulation membrane surface may be a promising strategy to solve this intractable problem for HD patients. Herein, we modified a nonthrombogenic polyethersulfone (PES) dialyzer membrane by grafting argatroban (AG) and methoxy polyethylene glycol amine (mPEG-NH
Identifiants
pubmed: 30907698
doi: 10.1080/09205063.2019.1595891
doi:
Substances chimiques
Anticoagulants
0
Coated Materials, Biocompatible
0
Fibrinolytic Agents
0
Indoles
0
Membranes, Artificial
0
Pipecolic Acids
0
Polymers
0
Sulfonamides
0
Sulfones
0
methoxy polyethylene glycol amine
0
polydopamine
0
polyether sulfone
25667-42-9
Polyethylene Glycols
3WJQ0SDW1A
Arginine
94ZLA3W45F
argatroban
IY90U61Z3S
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM