Salubrinal, a novel inhibitor of eIF-2α dephosphorylation, promotes erythropoiesis at early stage targeted by ufmylation pathway.
Anemia
/ chemically induced
Animals
Cinnamates
/ chemistry
Erythrocytes
/ drug effects
Erythropoiesis
/ drug effects
Eukaryotic Initiation Factor-2
/ metabolism
Fetus
/ cytology
Hemolysis
/ drug effects
Liver
/ cytology
Male
Mice, Inbred C57BL
Mice, Knockout
Models, Biological
Phenotype
Phenylhydrazines
Phosphorylation
/ drug effects
Protein Processing, Post-Translational
/ drug effects
Thiourea
/ analogs & derivatives
Up-Regulation
/ drug effects
DDRGK1
erythropoiesis
salubrinal
ufmylation
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
25
11
2018
revised:
12
02
2019
accepted:
14
02
2019
pubmed:
26
3
2019
medline:
27
5
2020
entrez:
26
3
2019
Statut:
ppublish
Résumé
Ufmylation was proved to play a crucial role in hematopoietic stem cell (HSC) survival and erythroid differentiation, ufmylation deficiency induces acute anemia and lethality of embryos and adults in mouse models. To screen some compounds to rescue phenotypes induced by gene deletion, in this study, we used DDRGK1
Substances chimiques
Cinnamates
0
Eukaryotic Initiation Factor-2
0
Phenylhydrazines
0
salubrinal
0
phenylhydrazine
064F424C9K
Thiourea
GYV9AM2QAG
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18560-18570Informations de copyright
© 2019 Wiley Periodicals, Inc.