Successful transplantation of kidneys from deceased donors with terminal acute kidney injury.
Acute Kidney Injury
/ mortality
Adolescent
Adult
Aged
Allografts
/ pathology
Delayed Graft Function
/ epidemiology
Donor Selection
/ standards
Female
Follow-Up Studies
Glomerular Filtration Rate
Graft Rejection
/ epidemiology
Graft Survival
Humans
Kidney
/ pathology
Kidney Failure, Chronic
/ mortality
Kidney Transplantation
/ adverse effects
Male
Middle Aged
Retrospective Studies
Survival Rate
Tissue Donors
Treatment Outcome
Young Adult
Acute kidney injury
deceased donors
expanded criteria donors
kidney graft survival
kidney transplantation
Journal
Renal failure
ISSN: 1525-6049
Titre abrégé: Ren Fail
Pays: England
ID NLM: 8701128
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
entrez:
27
3
2019
pubmed:
27
3
2019
medline:
17
4
2019
Statut:
ppublish
Résumé
There are many doubts with regards to accepting deceased kidneys with acute kidney injury (AKI) for transplantation. The aim of this study was to present the 5-years outcome of kidney transplantation cases where deceased donors developed AKI before organ procurement. Two hundred twenty-six deceased renal transplants were analyzed. Data regarding donors and recipients were collected. Terminal AKI was defined as terminal serum creatinine concentration higher than 1.99 mg/dL and 66 such cases were diagnosed. All kidney transplant recipients were followed for 60 months. AKI group presented more episodes of delayed graft function (DGF) compared to the non-AKI group (56% vs 35%, p < .05). No differences were observed between the groups in the rate of acute rejection episodes, kidney function as well as patient and graft survival. Transplants with AKI present more often DGF and comparable graft survival to transplants without AKI. Kidneys with AKI can be a valuable source of organs provided attentive selection and appropriate care of deceased donors.
Sections du résumé
BACKGROUND
BACKGROUND
There are many doubts with regards to accepting deceased kidneys with acute kidney injury (AKI) for transplantation.
PURPOSE
OBJECTIVE
The aim of this study was to present the 5-years outcome of kidney transplantation cases where deceased donors developed AKI before organ procurement.
METHODS
METHODS
Two hundred twenty-six deceased renal transplants were analyzed. Data regarding donors and recipients were collected. Terminal AKI was defined as terminal serum creatinine concentration higher than 1.99 mg/dL and 66 such cases were diagnosed. All kidney transplant recipients were followed for 60 months.
RESULTS
RESULTS
AKI group presented more episodes of delayed graft function (DGF) compared to the non-AKI group (56% vs 35%, p < .05). No differences were observed between the groups in the rate of acute rejection episodes, kidney function as well as patient and graft survival.
CONCLUSIONS
CONCLUSIONS
Transplants with AKI present more often DGF and comparable graft survival to transplants without AKI. Kidneys with AKI can be a valuable source of organs provided attentive selection and appropriate care of deceased donors.
Identifiants
pubmed: 30909784
doi: 10.1080/0886022X.2019.1590209
pmc: PMC6442227
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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