Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma.
AMP-Activated Protein Kinases
/ metabolism
Autophagy
/ drug effects
Autophagy-Related Protein 5
/ drug effects
Glioblastoma
/ drug therapy
Humans
Microtubule-Associated Proteins
Phenylurea Compounds
/ pharmacology
Pyridines
/ pharmacology
Sequestosome-1 Protein
/ metabolism
Signal Transduction
/ drug effects
TOR Serine-Threonine Kinases
/ drug effects
Transaminases
/ drug effects
Autophagosome accumulation
PSAT1
autophagy arrest
glioblastoma
regorafenib
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
pubmed:
27
3
2019
medline:
25
11
2020
entrez:
27
3
2019
Statut:
ppublish
Résumé
GBM (glioblastoma multiforme) is the most common and aggressive brain tumor with no curative options available. Therefore, it is imperative to develop novel potent therapeutic drugs for GBM treatment. Here, we show that regorafenib, an oral multi-kinase inhibitor, exhibits superior therapeutic efficacy over temozolomide, the first-line chemotherapeutic agent for GBM treatment both
Identifiants
pubmed: 30909789
doi: 10.1080/15548627.2019.1598752
pmc: PMC6984601
doi:
Substances chimiques
Autophagy-Related Protein 5
0
MAP1LC3B protein, human
0
Microtubule-Associated Proteins
0
Phenylurea Compounds
0
Pyridines
0
SQSTM1 protein, human
0
Sequestosome-1 Protein
0
regorafenib
24T2A1DOYB
Transaminases
EC 2.6.1.-
phosphoserine aminotransferase
EC 2.6.1.52
TOR Serine-Threonine Kinases
EC 2.7.11.1
AMP-Activated Protein Kinases
EC 2.7.11.31
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106-122Références
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