Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis.
Animals
Axons
/ pathology
Cell Differentiation
/ physiology
Cells, Cultured
Cellular Senescence
/ physiology
Humans
Induced Pluripotent Stem Cells
Multiple Sclerosis
/ physiopathology
Multiple Sclerosis, Chronic Progressive
/ physiopathology
Myelin Sheath
/ metabolism
Nerve Regeneration
/ physiology
Neural Stem Cells
/ physiology
Neurons
/ metabolism
Proteomics
/ methods
Rats
Remyelination
/ physiology
aging
neural progenitor cell
oligodendrocyte
proteomics
rapamycin
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
30 04 2019
30 04 2019
Historique:
pubmed:
27
3
2019
medline:
26
3
2020
entrez:
27
3
2019
Statut:
ppublish
Résumé
Cellular senescence is a form of adaptive cellular physiology associated with aging. Cellular senescence causes a proinflammatory cellular phenotype that impairs tissue regeneration, has been linked to stress, and is implicated in several human neurodegenerative diseases. We had previously determined that neural progenitor cells (NPCs) derived from induced pluripotent stem cell (iPSC) lines from patients with primary progressive multiple sclerosis (PPMS) failed to promote oligodendrocyte progenitor cell (OPC) maturation, whereas NPCs from age-matched control cell lines did so efficiently. Herein, we report that expression of hallmarks of cellular senescence were identified in SOX2
Identifiants
pubmed: 30910981
pii: 1818348116
doi: 10.1073/pnas.1818348116
pmc: PMC6500153
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9030-9039Subventions
Organisme : Chief Scientist Office
ID : CGA/18/20
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P016022/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S035915/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T015594/1
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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