MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients.

Adult Animals Disease Models, Animal Female Humans Inflammation / metabolism Male Matrix Metalloproteinase 9 / metabolism Mice Neuroimmunomodulation Oxidation-Reduction Oxidative Stress Receptor for Advanced Glycation End Products / metabolism Schizophrenia / metabolism

Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
11 2020
Historique:
received: 04 09 2018
accepted: 14 02 2019
revised: 11 02 2019
pubmed: 27 3 2019
medline: 16 3 2021
entrez: 27 3 2019
Statut: ppublish

Résumé

Various mechanisms involved in schizophrenia pathophysiology, such as dopamine dysregulation, glutamate/NMDA receptor dysfunction, neuroinflammation or redox imbalance, all appear to converge towards an oxidative stress "hub" affecting parvalbumine interneurones (PVI) and their perineuronal nets (PNN) (Lancet Psychiatry. 2015;2:258-70); (Nat Rev Neurosci. 2016;17:125-34). We aim to investigate underlying mechanisms linking oxidative stress with neuroinflammatory and their long-lasting harmful consequences. In a transgenic mouse of redox dysregulation carrying a permanent deficit of glutathione synthesis (gclm

Identifiants

DOI: 10.1038/s41380-019-0393-5 PMID: 30911107 PMC: PMC7577857
pubmed: 30911107
doi: 10.1038/s41380-019-0393-5
pii: 10.1038/s41380-019-0393-5
pmc: PMC7577857
doi:

Substances chimiques

Receptor for Advanced Glycation End Products 0
MMP9 protein, human EC 3.4.24.35
Matrix Metalloproteinase 9 EC 3.4.24.35
Mmp9 protein, mouse EC 3.4.24.35

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2889-2904

Commentaires et corrections

Type : ErratumIn

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Auteurs

Daniella Dwir (D)

Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois and University of Lausanne (CHUV-UNIL), Prilly-Lausanne, Switzerland.

Basilio Giangreco (B)

Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois and University of Lausanne (CHUV-UNIL), Prilly-Lausanne, Switzerland.

Lijing Xin (L)

Animal Imaging and Technology Core (AIT), Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Liliane Tenenbaum (L)

Laboratory of Cellular and Molecular Neurotherapies, Department of Clinical Neuroscience, CHUV, Lausanne, Switzerland.
ORCID: 0000-0003-4619-9660

Jan-Harry Cabungcal (JH)

Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois and University of Lausanne (CHUV-UNIL), Prilly-Lausanne, Switzerland.

Pascal Steullet (P)

Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois and University of Lausanne (CHUV-UNIL), Prilly-Lausanne, Switzerland.

Audrey Goupil (A)

Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois and University of Lausanne (CHUV-UNIL), Prilly-Lausanne, Switzerland.

Martine Cleusix (M)

Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois and University of Lausanne (CHUV-UNIL), Prilly-Lausanne, Switzerland.
Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Raoul Jenni (R)

Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois and University of Lausanne (CHUV-UNIL), Prilly-Lausanne, Switzerland.
Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Abdelwahed Chtarto (A)

Laboratory of Experimental Neurosurgery, Université Libre de Bruxelles, Erasme Hospital, 22, route de Lennik, B-1070, Bruxelles, Belgium.

Philipp S Baumann (PS)

Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois and University of Lausanne (CHUV-UNIL), Prilly-Lausanne, Switzerland.
Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Paul Klauser (P)

Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois and University of Lausanne (CHUV-UNIL), Prilly-Lausanne, Switzerland.
Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Philippe Conus (P)

Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois and University of Lausanne (CHUV-UNIL), Prilly-Lausanne, Switzerland.
Service of General Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Rabindra Tirouvanziam (R)

Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.

Michel Cuenod (M)

Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois and University of Lausanne (CHUV-UNIL), Prilly-Lausanne, Switzerland.

Kim Q Do (KQ)

Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois and University of Lausanne (CHUV-UNIL), Prilly-Lausanne, Switzerland. Kim.Do@chuv.ch.
ORCID: 0000-0003-1968-1646

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › MMP9/RAGE pathway overactivation mediates...
questionsmedicales.fr › Eucaryotes › Animaux › MMP9/RAGE pathway overactivation mediates...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › MMP9/RAGE pathway overactivation mediates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › MMP9/RAGE pathway overactivation mediates...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › MMP9/RAGE pathway overactivation mediates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Secreted matrix metalloproteinases › Matrix metalloproteinase 9 › MMP9/RAGE pathway overactivation mediates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › MMP9/RAGE pathway overactivation mediates...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Neuro-immunomodulation › MMP9/RAGE pathway overactivation mediates...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › MMP9/RAGE pathway overactivation mediates...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › MMP9/RAGE pathway overactivation mediates...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Récepteur spécifique des produits finaux de glycosylation avancée › MMP9/RAGE pathway overactivation mediates...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › MMP9/RAGE pathway overactivation mediates...