Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
26 03 2019
26 03 2019
Historique:
received:
06
09
2017
accepted:
13
03
2019
entrez:
28
3
2019
pubmed:
28
3
2019
medline:
2
10
2020
Statut:
epublish
Résumé
Endoplasmic reticulum (ER) stress in beta cells is an important pathogenic component of both type 1 and type 2 diabetes mellitus, as well as genetic forms of diabetes, especially Wolfram syndrome. However, there are currently no convenient ways to assess ER stress in beta cells, raising the need for circulating ER stress markers indicative of beta cell health. Here we show that pancreatic stone protein/regenerating protein (PSP/reg) is a potential biomarker for ER stressed beta cells. PSP/reg levels are elevated in cell culture and mouse models of Wolfram syndrome, a prototype of ER stress-induced diabetes. Moreover, PSP/reg expression is induced by the canonical chemical inducers of ER stress, tunicamycin and thapsigargin. Circulating PSP/reg levels are also increased in some patients with Wolfram syndrome. Our results therefore reveal PSP/reg as a potential biomarker for beta cells under chronic ER stress, as is the case in Wolfram syndrome.
Identifiants
pubmed: 30914711
doi: 10.1038/s41598-019-41604-4
pii: 10.1038/s41598-019-41604-4
pmc: PMC6435683
doi:
Substances chimiques
Biomarkers
0
Lithostathine
0
Membrane Proteins
0
REG1A protein, human
0
Reg1 protein, mouse
0
wolframin protein
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5199Subventions
Organisme : NIDDK NIH HHS
ID : R21 DK113487
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD070855
Pays : United States
Organisme : NIDDK NIH HHS
ID : P60 DK020579
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020579
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK112921
Pays : United States
Organisme : NCATS NIH HHS
ID : UH2 TR002065
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD043010
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056341
Pays : United States
Organisme : NIDDK NIH HHS
ID : F30 DK111070
Pays : United States
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