The Kinome of Human Alveolar Type II and Basal Cells, and Its Reprogramming in Lung Cancer.
Adenocarcinoma
/ enzymology
Adult Stem Cells
/ enzymology
Alveolar Epithelial Cells
/ enzymology
Animals
Carcinoma, Squamous Cell
/ enzymology
Cell Lineage
Cell Transformation, Neoplastic
Cells, Cultured
Enzyme Induction
Humans
Lung
/ cytology
Lung Neoplasms
/ enzymology
Mice
Neoplasm Proteins
/ analysis
Neoplastic Stem Cells
/ enzymology
Protein-Tyrosine Kinases
/ analysis
RNA, Messenger
/ analysis
RNA, Neoplasm
/ analysis
Transcriptome
alveolar type II cells
basal cells
kinome
lung adenocarcinoma
lung squamous cell carcinoma
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
pubmed:
28
3
2019
medline:
6
5
2020
entrez:
28
3
2019
Statut:
ppublish
Résumé
The discovery of mutant tyrosine kinases as oncogenic drivers of lung adenocarcinomas has changed the basic understanding of lung cancer development and therapy. Yet, expressed kinases (kinome) in lung cancer progenitor cells, as well as whether kinase expression and the overall kinome changes or is reprogrammed upon transformation, is incompletely understood. We hypothesized that the kinome differs between lung cancer progenitor cells, alveolar type II cells (ATII), and basal cells (BC) and that their respective kinomes undergo distinct lineage-specific reprogramming to adenocarcinomas and squamous cell carcinomas upon transformation. We performed RNA sequencing on freshly isolated human ATII, BC, and lung cancer cell lines to define the kinome in nontransformed cells and transformed cells. Our studies identified a unique kinome for ATII and BC and changes in their kinome upon transformation to their respective carcinomas.
Identifiants
pubmed: 30917006
doi: 10.1165/rcmb.2018-0283OC
pmc: PMC6775950
doi:
Substances chimiques
Neoplasm Proteins
0
RNA, Messenger
0
RNA, Neoplasm
0
Protein-Tyrosine Kinases
EC 2.7.10.1
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
481-491Subventions
Organisme : NCI NIH HHS
ID : P50 CA058187
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111674
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118171
Pays : United States
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