The Role of Tyrosine Phosphorylation of Protein Kinase C Delta in Infection and Inflammation.
PKC
PKCδ
inflammation
microfluidics
phosphorylation
sepsis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Mar 2019
26 Mar 2019
Historique:
received:
07
03
2019
revised:
15
03
2019
accepted:
22
03
2019
entrez:
29
3
2019
pubmed:
29
3
2019
medline:
10
7
2019
Statut:
epublish
Résumé
Protein Kinase C (PKC) is a family composed of phospholipid-dependent serine/threonine kinases that are master regulators of inflammatory signaling. The activity of different PKCs is context-sensitive and these kinases can be positive or negative regulators of signaling pathways. The delta isoform (PKCδ) is a critical regulator of the inflammatory response in cancer, diabetes, ischemic heart disease, and neurodegenerative diseases. Recent studies implicate PKCδ as an important regulator of the inflammatory response in sepsis. PKCδ, unlike other members of the PKC family, is unique in its regulation by tyrosine phosphorylation, activation mechanisms, and multiple subcellular targets. Inhibition of PKCδ may offer a unique therapeutic approach in sepsis by targeting neutrophil-endothelial cell interactions. In this review, we will describe the overall structure and function of PKCs, with a focus on the specific phosphorylation sites of PKCδ that determine its critical role in cell signaling in inflammatory diseases such as sepsis. Current genetic and pharmacological tools, as well as in vivo models, that are used to examine the role of PKCδ in inflammation and sepsis are presented and the current state of emerging tools such as microfluidic assays in these studies is described.
Identifiants
pubmed: 30917487
pii: ijms20061498
doi: 10.3390/ijms20061498
pmc: PMC6471617
pii:
doi:
Substances chimiques
Protein Kinase C-delta
EC 2.7.11.13
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM114359
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM134701
Pays : United States
Organisme : National Institute of Health
ID : GM114359
Organisme : American Heart Association
ID : 16GRNT29980001
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