Varicella-zoster Virus Related Pulmonary Granulomas in Which Varicella-zoster Virus DNA Was Demonstrated in a Thoracoscopic Lung Biopsy Specimen.
Acyclovir
/ therapeutic use
Adult
Antiviral Agents
/ therapeutic use
Cyclophosphamide
/ therapeutic use
DNA, Viral
/ isolation & purification
Granuloma
/ genetics
Humans
Male
Pneumonia
/ etiology
Polymerase Chain Reaction
Prednisolone
/ therapeutic use
Procarbazine
/ therapeutic use
Tomography, X-Ray Computed
Treatment Outcome
Varicella Zoster Virus Infection
/ complications
Vincristine
/ therapeutic use
malignant lymphoma
pulmonary granulomas
varicella pneumonia
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Jul 2019
15 Jul 2019
Historique:
pubmed:
29
3
2019
medline:
13
11
2019
entrez:
29
3
2019
Statut:
ppublish
Résumé
A 43-year-old man with malignant lymphoma who had been treated with the cyclosphamide, vincrstine, procarbazine, and prednisolone (C-MOPP) regimen was admitted to our hospital with skin eruption. He was diagnosed to have varicella, and treatment with acyclovir and immune globulin was started. Chest computed tomography revealed multiple nodules in the both lung fields. Diagnostic thoracoscopic lung biopsy specimens revealed granuloma formation, and polymerase chain reaction testing revealed the presence of varicella-zoster virus DNA in the granulomatous tissue. It was unusual for the lung nodule in varicella pneumonia to increase in size over time in a patient who had undergone antiviral therapy, while also demonstrating multiple granulomas.
Identifiants
pubmed: 30918176
doi: 10.2169/internalmedicine.2021-18
pmc: PMC6702000
doi:
Substances chimiques
Antiviral Agents
0
DNA, Viral
0
Procarbazine
35S93Y190K
Vincristine
5J49Q6B70F
Cyclophosphamide
8N3DW7272P
Prednisolone
9PHQ9Y1OLM
Acyclovir
X4HES1O11F
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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