The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome.
Lynch syndrome
endometrial cancer
guidance
screening
surveillance
Journal
Genetics in medicine : official journal of the American College of Medical Genetics
ISSN: 1530-0366
Titre abrégé: Genet Med
Pays: United States
ID NLM: 9815831
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
22
11
2018
accepted:
06
03
2019
pubmed:
29
3
2019
medline:
18
3
2020
entrez:
29
3
2019
Statut:
ppublish
Résumé
There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients. Stakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice. Guidance was developed in four key areas: (1) whether women with gynecological cancer should be screened for Lynch syndrome and (2) how this should be done, (3) whether there was a role for gynecological surveillance in women at risk of Lynch syndrome, and (4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer. This document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.
Identifiants
pubmed: 30918358
doi: 10.1038/s41436-019-0489-y
pii: S1098-3600(21)04493-2
pmc: PMC6774998
doi:
Types de publication
Practice Guideline
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2390-2400Subventions
Organisme : Cancer Research UK
ID : 16892
Pays : United Kingdom
Organisme : Department of Health
ID : NIHR-CS-012-009
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 27963
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA016058
Pays : United States
Organisme : Cancer Research UK
ID : 27047
Pays : United Kingdom
Organisme : Department of Health
ID : IS-BRC-1215-20007
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M018431/1
Pays : United Kingdom
Organisme : Department of Health
ID : NF-SI- 0513-10076
Pays : United Kingdom
Investigateurs
Angel Alonso Sanchez
(AA)
Mark J Arends
(MJ)
James Bolton
(J)
Tjalling Bosse
(T)
John Burn
(J)
Emma J Crosbie
(EJ)
David Church
(D)
Joanna M Cornes
(JM)
Robin Crawford
(R)
Karen Donnelly
(K)
Diana Eccles
(D)
Richard J Edmondson
(RJ)
D Gareth Evans
(DG)
Ian M Frayling
(IM)
Sadaf Ghaem-Maghami
(S)
Paula Gollop
(P)
Selina Goodman
(S)
Heather Hampel
(H)
Shirley Hodgson
(S)
Noah D Kauff
(ND)
Henry C Kitchener
(HC)
Sarah J Kitson
(SJ)
Fiona Lalloo
(F)
Anne Lowry
(A)
Ranjit Manchanda
(R)
Raymond F T McMahon
(RFT)
Rhona J McVey
(RJ)
Usha Menon
(U)
Tracie Miles
(T)
Gabriela Moeslein
(G)
Pal Moller
(P)
Kevin J Monahan
(KJ)
Adam Rosenthal
(A)
Neil A J Ryan
(NAJ)
Peter Sasieni
(P)
Mourad W Seif
(MW)
Pauline Skarrott
(P)
Naveena Singh
(N)
Tristan M Snowsill
(TM)
Robert Steele
(R)
Astrid Stormoken
(A)
Helen Stringfellow
(H)
Marc Tischkowitz
(M)
Andrew Wallace
(A)
Luciya Whyte
(L)
Nafisa Wilkinson
(N)
Godfrey Wilson
(G)
Jo Wilson
(J)
Nick Wood
(N)
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