Structural variation in the gut microbiome associates with host health.
Adaptation, Physiological
/ genetics
Bacteria
/ classification
Butyrates
/ metabolism
Cohort Studies
Disease Susceptibility
/ microbiology
Ecosystem
Eubacterium
/ genetics
Feces
/ microbiology
Gastrointestinal Microbiome
/ genetics
Genes, Bacterial
/ genetics
Genetic Variation
Health
Host Microbial Interactions
/ genetics
Humans
Inositol
/ metabolism
Metagenomics
Microbial Viability
/ genetics
Risk Factors
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
27
02
2018
accepted:
21
02
2019
pubmed:
29
3
2019
medline:
20
8
2019
entrez:
29
3
2019
Statut:
ppublish
Résumé
Differences in the presence of even a few genes between otherwise identical bacterial strains may result in critical phenotypic differences. Here we systematically identify microbial genomic structural variants (SVs) and find them to be prevalent in the human gut microbiome across phyla and to replicate in different cohorts. SVs are enriched for CRISPR-associated and antibiotic-producing functions and depleted from housekeeping genes, suggesting that they have a role in microbial adaptation. We find multiple associations between SVs and host disease risk factors, many of which replicate in an independent cohort. Exploring genes that are clustered in the same SV, we uncover several possible mechanistic links between the microbiome and its host, including a region in Anaerostipes hadrus that encodes a composite inositol catabolism-butyrate biosynthesis pathway, the presence of which is associated with lower host metabolic disease risk. Overall, our results uncover a nascent layer of variability in the microbiome that is associated with microbial adaptation and host health.
Identifiants
pubmed: 30918406
doi: 10.1038/s41586-019-1065-y
pii: 10.1038/s41586-019-1065-y
doi:
Substances chimiques
Butyrates
0
Inositol
4L6452S749
Types de publication
Journal Article
Langues
eng
Pagination
43-48Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
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