Coordination of rapid cholinergic and dopaminergic signaling in striatum during spontaneous movement.
acetylcholine
dopamine
in vivo
motor control
mouse
neuroscience
optical recording
striatum
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
28 03 2019
28 03 2019
Historique:
received:
05
01
2019
accepted:
26
03
2019
pubmed:
29
3
2019
medline:
21
3
2020
entrez:
29
3
2019
Statut:
epublish
Résumé
Interplay between dopaminergic and cholinergic neuromodulation in the striatum is crucial for movement control, with prominent models proposing pro-kinetic and anti-kinetic effects of dopamine and acetylcholine release, respectively. However, the natural, movement-related signals of striatum cholinergic neurons and their relationship to simultaneous variations in dopamine signaling are unknown. Here, functional optical recordings in mice were used to establish rapid cholinergic signals in dorsal striatum during spontaneous movements. Bursts across the cholinergic population occurred at transitions between movement states and were marked by widespread network synchronization which diminished during sustained locomotion. Simultaneous cholinergic and dopaminergic recordings revealed distinct but coordinated sub-second signals, suggesting a new model where cholinergic population synchrony signals rapid changes in movement states while dopamine signals the drive to enact or sustain those states.
Identifiants
pubmed: 30920369
doi: 10.7554/eLife.44903
pii: 44903
pmc: PMC6457892
doi:
pii:
Banques de données
Dryad
['10.5061/dryad.j1fd7']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIMH NIH HHS
ID : R01 MH110556
Pays : United States
Organisme : NIH HHS
ID : R01MH110556
Pays : United States
Organisme : NIH HHS
ID : T32 AG20506
Pays : United States
Informations de copyright
© 2019, Howe et al.
Déclaration de conflit d'intérêts
MH, IR, AA, AL, MA, DD No competing interests declared
Références
JAMA. 1961 Sep 9;177:665-70
pubmed: 13773933
Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):E2180-8
pubmed: 27001837
J Neurophysiol. 2006 Apr;95(4):2391-403
pubmed: 16407429
Front Synaptic Neurosci. 2014 Oct 21;6:22
pubmed: 25374536
J Neurosci. 2016 Feb 17;36(7):2202-11
pubmed: 26888930
Proc Natl Acad Sci U S A. 2016 May 31;113(22):E3159-68
pubmed: 27185924
Nature. 2016 Jul 28;535(7613):505-10
pubmed: 27398617
Front Syst Neurosci. 2017 Jul 24;11:52
pubmed: 28790898
Neuron. 2004 Jul 8;43(1):133-43
pubmed: 15233923
Science. 2000 Jul 28;289(5479):633-7
pubmed: 10915629
Neuropsychopharmacology. 2016 Nov;41(12):2830-2838
pubmed: 27240658
Front Integr Neurosci. 2015 May 27;9:39
pubmed: 26074791
Neuron. 2016 Jun 1;90(5):1071-1085
pubmed: 27210555
Proc Natl Acad Sci U S A. 1984 Aug;81(15):4998-5001
pubmed: 6589643
Neuron. 2012 Jul 12;75(1):58-64
pubmed: 22794260
Cell Rep. 2015 Oct 27;13(4):657-666
pubmed: 26489458
Eur J Neurosci. 2009 Aug;30(3):515-26
pubmed: 19656171
Nat Neurosci. 2016 Jun;19(6):845-54
pubmed: 27110917
Neuron. 2006 May 4;50(3):443-52
pubmed: 16675398
Front Syst Neurosci. 2011 May 31;5:36
pubmed: 21660109
Nat Neurosci. 2018 Aug;21(8):1072-1083
pubmed: 30038277
Nat Neurosci. 2009 Sep;12(9):1121-8
pubmed: 19668198
Neurobiol Dis. 2016 Jul;91:47-58
pubmed: 26921469
Can Med Assoc J. 1962 Oct 13;87:802-7
pubmed: 13966498
J Neurosci. 2011 Aug 3;31(31):11133-43
pubmed: 21813675
Handb Exp Pharmacol. 2012;(208):223-41
pubmed: 22222701
J Neurosci. 2018 Apr 4;38(14):3547-3558
pubmed: 29523623
J Neurosci. 2014 Feb 5;34(6):2299-304
pubmed: 24501368
Curr Opin Neurobiol. 2011 Jun;21(3):425-32
pubmed: 21550798
Science. 2010 Dec 17;330(6011):1677-81
pubmed: 21164015
Exp Brain Res. 1997 Oct;116(3):456-66
pubmed: 9372294
J Neurophysiol. 1995 Mar;73(3):1234-52
pubmed: 7608768
J Neurosci. 2015 Nov 11;35(45):15214-26
pubmed: 26558790
J Neurosci. 2015 Jun 24;35(25):9424-31
pubmed: 26109665
Neuron. 2010 Aug 12;67(3):466-79
pubmed: 20696383
Eur J Neurosci. 2018 May;47(10):1148-1158
pubmed: 28677242
J Neurosci. 1990 Feb;10(2):508-19
pubmed: 2303856
Nature. 2013 Jul 18;499(7458):295-300
pubmed: 23868258
J Neurosci. 2003 Sep 17;23(24):8489-97
pubmed: 13679417
Nat Neurosci. 2018 Nov;21(11):1563-1573
pubmed: 30323275
Trends Neurosci. 2007 Jun;30(6):299-306
pubmed: 17420057
Neuroscience. 2017 Sep 30;360:81-94
pubmed: 28768155
Elife. 2018 Mar 26;7:
pubmed: 29578407
Neuron. 2014 Dec 3;84(5):1079-90
pubmed: 25467986
Nature. 2018 Feb 8;554(7691):244-248
pubmed: 29420469
Science. 1995 Apr 14;268(5208):297-300
pubmed: 7716524
Trends Neurosci. 1994 Jun;17(6):228-33
pubmed: 7521083
J Neurosci. 2014 Jun 18;34(25):8557-69
pubmed: 24948810
Behav Brain Res. 2004 Sep 23;154(1):245-53
pubmed: 15302131
Eur J Neurosci. 2018 May;47(10):1194-1205
pubmed: 29359362
Psychopharmacology (Berl). 2007 Apr;191(3):507-20
pubmed: 17031711
Front Comput Neurosci. 2013 Mar 18;7:13
pubmed: 23515615
Exp Brain Res. 1999 Oct;128(4):531-4
pubmed: 10541747
J Neurophysiol. 1996 Sep;76(3):2083-8
pubmed: 8890317
J Neurophysiol. 2001 Feb;85(2):960-76
pubmed: 11160526
Exp Brain Res. 1991;84(3):672-5
pubmed: 1864338
Neuron. 2018 Jun 6;98(5):918-925.e3
pubmed: 29754751
Neuron. 2010 Jul 29;67(2):175-8
pubmed: 20670826
Nat Neurosci. 2016 Jan;19(1):34-6
pubmed: 26642087
Neurosci Lett. 1996 Jan 26;203(3):147-50
pubmed: 8742014
Exp Neurol. 2016 Dec;286:32-39
pubmed: 27658674
Eur J Neurosci. 2002 Dec;16(11):2017-26
pubmed: 12473069
Neuron. 2002 Mar 14;33(6):973-82
pubmed: 11906702
Cell. 2015 Sep 10;162(6):1418-30
pubmed: 26359992
J Neurosci. 1994 Jun;14(6):3969-84
pubmed: 8207500
Science. 1980 May 30;208(4447):1057-9
pubmed: 6990490
Elife. 2019 Mar 28;8:
pubmed: 30920369
eNeuro. 2019 Jan 18;6(1):
pubmed: 30671536
Science. 2018 Jun 29;360(6396):
pubmed: 29853555
Neuron. 2014 Jun 4;82(5):1145-56
pubmed: 24908491
J Neurosci. 2016 Aug 31;36(35):9161-72
pubmed: 27581457
Neuron. 2010 Jul 29;67(2):294-307
pubmed: 20670836
Nature. 2013 Feb 14;494(7436):238-42
pubmed: 23354054
Science. 1994 Jul 15;265(5170):412-5
pubmed: 8023166
Cereb Cortex. 2016 Oct 1;26(11):4160-4169
pubmed: 27566978