Glycoprotein V is a relevant immune target in patients with immune thrombocytopenia.
Animals
Autoantibodies
/ immunology
Autoantigens
/ immunology
Blood Platelets
/ immunology
Disease Models, Animal
Disease Susceptibility
/ immunology
Female
Humans
Male
Mice
Mice, Inbred NOD
Mice, SCID
Phagocytosis
Platelet Membrane Glycoproteins
/ immunology
Prevalence
Protein Binding
/ immunology
Purpura, Thrombocytopenic, Idiopathic
/ epidemiology
Journal
Haematologica
ISSN: 1592-8721
Titre abrégé: Haematologica
Pays: Italy
ID NLM: 0417435
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
05
11
2018
accepted:
20
03
2019
pubmed:
30
3
2019
medline:
19
5
2020
entrez:
30
3
2019
Statut:
ppublish
Résumé
Platelet autoantibody-induced platelet clearance represents a major pathomechanism in immune thrombocytopenia (ITP). There is growing evidence for clinical differences between anti-glycoprotein IIb/IIIa and anti-glycoprotein Ib/IX mediated ITP. Glycoprotein V is a well characterized target antigen in Varicella-associated and drug-induced thrombocytopenia. We conducted a systematic study assessing the prevalence and functional capacity of autoantibodies against glycoprotein V. A total of 1140 patients were included. In one-third of patients, platelet-bound autoantibodies against glycoproteins Ib/IX, IIb/IIIa, or V were detected in a monoclonal antibody immobilization of platelet antigen assay; platelet-bound autoantiglycoprotein V was present in the majority of samples (222 out of 343, 64.7%). Investigation of patient sera revealed the presence of free autoantibodies against glycoprotein V in 13.5% of these patients by an indirect monoclonal antibody immobilization of platelet antigen assay, but in 39.6% by surface plasmon resonance technology. These antibodies showed significantly lower avidity (association/dissociation ratio 0.32±0.13
Identifiants
pubmed: 30923095
pii: haematol.2018.211086
doi: 10.3324/haematol.2018.211086
pmc: PMC6545841
doi:
Substances chimiques
Autoantibodies
0
Autoantigens
0
Platelet Membrane Glycoproteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1237-1243Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright© 2019 Ferrata Storti Foundation.
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