Association of a Functional Polymorphism in the

Adult Female Genotype Humans Inflammation Mediators / metabolism Male Neuralgia / genetics Polymorphism, Single Nucleotide Spinal Cord Injuries / complications alpha7 Nicotinic Acetylcholine Receptor / genetics
CHRFAM7A gene SCI cytokine inflammation pain

Journal

Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626

Informations de publication

Date de publication:
01 11 2019
Historique:
pubmed: 30 3 2019
medline: 11 11 2020
entrez: 30 3 2019
Statut: ppublish

Résumé

The alpha 7 nicotinic acetylcholine receptor, α7 nAChR, plays a central role in regulating inflammatory responses. Previous studies showed that pharmacological inhibitors of α7nAChR have a pro-inflammatory effect, increasing the circulating levels of cytokines such as tumor necrosis factor alpha (TNFα). This study focused on how genetic polymorphisms of the partially duplicated α7nAChR gene (

Identifiants

DOI: 10.1089/neu.2018.6200 PMID: 30924722
pubmed: 30924722
doi: 10.1089/neu.2018.6200
doi:

Substances chimiques

Chrna7 protein, human 0
Inflammation Mediators 0
alpha7 Nicotinic Acetylcholine Receptor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3026-3033

Auteurs

Wan Huang (W)

Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Nadine Kabbani (N)

School of Systems Biology, George Mason University, Fairfax, Virginia.

Tricia K Brannan (TK)

Inova Neuroscience Institute, Inova Health System, Falls Church, Virginia.

Ming Kuan Lin (MK)

School of Systems Biology, George Mason University, Fairfax, Virginia.

Mark M Theiss (MM)

Department of Orthopedic Services, Inova Fairfax Hospital, Falls Church, Virginia.

John F Hamilton (JF)

Inova Neuroscience Institute, Inova Health System, Falls Church, Virginia.

James M Ecklund (JM)

Inova Neuroscience Institute, Inova Health System, Falls Church, Virginia.

Yvette P Conley (YP)

School of Nursing, Pittsburgh, Bioengineering McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

Yoram Vodovotz (Y)

Department of Surgery, Center for Inflammation and Regenerative Modeling, Bioengineering McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

David Brienza (D)

Rehabilitation Science and Technology, Bioengineering McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania.

Amy K Wagner (AK)

Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Emily Robbins (E)

Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Gwendolyn A Sowa (GA)

Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania.

Robert H Lipsky (RH)

School of Systems Biology, George Mason University, Fairfax, Virginia.
Inova Neuroscience Institute, Inova Health System, Falls Church, Virginia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Association of a Functional Polymorphism in the
questionsmedicales.fr › Phénomènes génétiques › Génotype › Association of a Functional Polymorphism in the
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of a Functional Polymorphism in the
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Association of a Functional Polymorphism in the
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Névralgie › Association of a Functional Polymorphism in the
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Association of a Functional Polymorphism in the
questionsmedicales.fr › Plaies et blessures › Traumatismes de la moelle épinière › Association of a Functional Polymorphism in the
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteurs nicotiniques › Récepteur nicotinique de l'acétylcholine alpha7 › Association of a Functional Polymorphism in the