Molecular architecture of the presynaptic terminal.

Animals Cryoelectron Microscopy Neurotransmitter Agents / metabolism Presynaptic Terminals / metabolism

Journal

Current opinion in structural biology
ISSN: 1879-033X
Titre abrégé: Curr Opin Struct Biol
Pays: England
ID NLM: 9107784

Informations de publication

Date de publication:
02 2019
Historique:
received: 29 11 2018
revised: 11 01 2019
accepted: 26 01 2019
pubmed: 30 3 2019
medline: 18 2 2020
entrez: 30 3 2019
Statut: ppublish

Résumé

Neurotransmitter release at the presynaptic terminal is one of the fundamental processes in neuronal communication. It is a complex process comprising signaling pathways that exert a precise spatio-temporal coordination to prepare and bring synaptic vesicles to exocytosis. While many molecular components involved have been identified, their direct observation at different stages of the neurotransmitter release is lacking. Three-dimensional imaging by electron tomography provided remarkable views of the synaptic vesicles and the cytomatrix. Imaging fully hydrated, vitrified samples allowed a direct visualization, precise localization and a quantitative characterization of pleomorphic synaptic vesicle-bound complexes in situ, as well as the elucidation of their function in the neurotransmitter release.

Identifiants

DOI: 10.1016/j.sbi.2019.01.008 PMID: 30925443
pubmed: 30925443
pii: S0959-440X(18)30181-7
doi: 10.1016/j.sbi.2019.01.008
pii:
doi:

Substances chimiques

Neurotransmitter Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

129-138

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Benoît Zuber (B)

Institute of Anatomy, University of Bern, Bern 3012, Switzerland.

Vladan Lučić (V)

Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany. Electronic address: vladan@biochem.mpg.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Molecular architecture of the presynaptic terminal.
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Molecular architecture of the presynaptic terminal.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Molecular architecture of the presynaptic terminal.
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Terminaisons présynaptiques › Molecular architecture of the presynaptic terminal.