Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto's thyroiditis.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 03 2019
29 03 2019
Historique:
received:
20
07
2018
accepted:
18
03
2019
entrez:
31
3
2019
pubmed:
31
3
2019
medline:
10
10
2020
Statut:
epublish
Résumé
Thyroid antibodies against thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) are key markers of Hashimoto's thyroiditis (HT), the most common autoimmune thyroid disorder. Genetic determinants of thyroid antibodies are still poorly known, especially as they were not studied in patients with thyroid diseases. We performed the first genome-wide association analysis of thyroid antibodies in 430 HT patients that may be considered as population extremes for thyroid antibodies distribution. We detected two suggestively associated genetic variants with TgAb, rs6972286 close to ANKRD7 and LSM8 (P = 2.34 × 10
Identifiants
pubmed: 30926877
doi: 10.1038/s41598-019-41850-6
pii: 10.1038/s41598-019-41850-6
pmc: PMC6440971
doi:
Substances chimiques
Autoantibodies
0
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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