The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
29 03 2019
29 03 2019
Historique:
received:
14
08
2018
accepted:
07
03
2019
entrez:
31
3
2019
pubmed:
31
3
2019
medline:
6
5
2019
Statut:
epublish
Résumé
Malaria infections occurring below the limit of detection of standard diagnostics are common in all endemic settings. However, key questions remain surrounding their contribution to sustaining transmission and whether they need to be detected and targeted to achieve malaria elimination. In this study we analyse a range of malaria datasets to quantify the density, detectability, course of infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission settings compared to individuals in higher transmission settings. In cohort studies, subpatent infections are found to be predictive of future periods of patent infection and in membrane feeding studies, individuals infected with subpatent asexual parasite densities are found to be approximately a third as infectious to mosquitoes as individuals with patent (asexual parasite) infection. These results indicate that subpatent infections contribute to the infectious reservoir, may be long lasting, and require more sensitive diagnostics to detect them in lower transmission settings.
Identifiants
pubmed: 30926893
doi: 10.1038/s41467-019-09441-1
pii: 10.1038/s41467-019-09441-1
pmc: PMC6440965
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1433Subventions
Organisme : Medical Research Council
ID : MR/R010161/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R015600/1
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Références
Clin Infect Dis. 2018 Jun 1;66(12):1883-1891
pubmed: 29304258
Am J Trop Med Hyg. 2017 Nov;97(5):1540-1550
pubmed: 28820709
PLoS One. 2015 May 21;10(5):e0126747
pubmed: 25996916
J Med Entomol. 2004 Mar;41(2):201-8
pubmed: 15061279
Malar J. 2011 Aug 24;10:247
pubmed: 21864343
Trans R Soc Trop Med Hyg. 1992 Jul-Aug;86(4):355-8
pubmed: 1359683
PLoS Med. 2012 Jan;9(1):e1001165
pubmed: 22303287
Infect Immun. 2001 Dec;69(12):7783-92
pubmed: 11705960
Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5108-13
pubmed: 15792998
PLoS Pathog. 2017 Jan 12;13(1):e1006108
pubmed: 28081253
Infect Genet Evol. 2015 Jul;33:110-7
pubmed: 25917493
PLoS One. 2010 Feb 04;5(2):e9047
pubmed: 20140220
Am J Trop Med Hyg. 1998 Jul;59(1):115-23
pubmed: 9684638
Malar J. 2016 Mar 24;15:181
pubmed: 27013512
PLoS Med. 2015 Mar 03;12(3):e1001788
pubmed: 25734259
Lancet Infect Dis. 2018 May;18(5):565-572
pubmed: 29398388
Clin Infect Dis. 2018 Sep 14;67(7):1045-1052
pubmed: 29546346
Infect Immun. 2012 Apr;80(4):1583-92
pubmed: 22252876
Am J Trop Med Hyg. 2016 Jun 1;94(6):1259-65
pubmed: 27001760
Am J Trop Med Hyg. 2007 Dec;77(6 Suppl):119-27
pubmed: 18165483
Expert Rev Anti Infect Ther. 2013 Jun;11(6):623-39
pubmed: 23750733
Malar J. 2016 Apr 14;15:213
pubmed: 27075879
Microbes Infect. 2006 Jun;8(7):1663-70
pubmed: 16730211
J Clin Microbiol. 2014 Sep;52(9):3303-9
pubmed: 24989601
Malar J. 2017 Mar 3;16(1):99
pubmed: 28253867
Malar J. 2014 Nov 18;13:433
pubmed: 25404207
Epidemics. 2011 Jun;3(2):109-18
pubmed: 21624782
Infect Immun. 2012 Jun;80(6):2240-6
pubmed: 22451520
Trans R Soc Trop Med Hyg. 2010 May;104(5):343-50
pubmed: 20106494
PLoS One. 2017 Jan 17;12(1):e0169037
pubmed: 28095434
PLoS One. 2009 Dec 22;4(12):e8410
pubmed: 20027314
Sci Rep. 2013 Dec 04;3:3418
pubmed: 24301557
Malar J. 2016 Oct 4;15(1):496
pubmed: 27716244
Nat Commun. 2012;3:1237
pubmed: 23212366
Sci Rep. 2016 Dec 16;6:39183
pubmed: 27982132
PLoS One. 2012;7(9):e45542
pubmed: 23029082
J Infect Dis. 2019 Apr 16;219(9):1499-1509
pubmed: 30500927
Malar J. 2014 Dec 16;13:500
pubmed: 25515943
Malar J. 2015 Jan 28;14:25
pubmed: 25888818
PLoS One. 2013;8(2):e56677
pubmed: 23437209
Am J Trop Med Hyg. 2015 Mar;92(3):648-52
pubmed: 25624409
Clin Chem. 2015 Jun;61(6):821-8
pubmed: 25964304
Malar J. 2018 Apr 17;17(1):170
pubmed: 29665803
Malar J. 2015 Aug 04;14:294
pubmed: 26238109
Am J Trop Med Hyg. 1999 Jul;61(1 Suppl):4-19
pubmed: 10432041
Am J Trop Med Hyg. 2006 Jun;74(6):944-50
pubmed: 16760501
Lancet. 2018 May 12;391(10133):1916-1926
pubmed: 29703425
Malar J. 2015 Jan 28;14:43
pubmed: 25627037
PLoS Pathog. 2018 May 9;14(5):e1007034
pubmed: 29742161
J Infect Dis. 2016 Apr 15;213(8):1322-9
pubmed: 26681777
J Infect Dis. 2009 Nov 15;200(10):1509-17
pubmed: 19848588
J Infect Dis. 2016 May 1;213(9):1516-7
pubmed: 26908734
Am J Trop Med Hyg. 1997 May;56(5):538-47
pubmed: 9180605
Nat Commun. 2017 Oct 26;8(1):1133
pubmed: 29074880
Am J Trop Med Hyg. 1954 Mar;3(2):219-24
pubmed: 13138823
Crit Rev Clin Lab Sci. 2016;53(2):87-105
pubmed: 26376713
Trends Parasitol. 2015 Jul;31(7):287-96
pubmed: 25985898
Nat Rev Microbiol. 2014 Dec;12(12):833-40
pubmed: 25329408
J Infect Dis. 2014 Apr 1;209(7):1136-43
pubmed: 24265441
Trans R Soc Trop Med Hyg. 1999 Feb;93 Suppl 1:47-51
pubmed: 10450426
Malar J. 2013 Jul 01;12:221
pubmed: 23815811
J Infect Dis. 2016 Jan 1;213(1):90-9
pubmed: 26142435
Am J Trop Med Hyg. 2003 Jun;68(6):734-42
pubmed: 12887036
J R Soc Interface. 2015 Mar 6;12(104):20141379
pubmed: 25673299