Prevention of complications from use of conventional immunosuppressants: a critical review.
Calcineurin inhibitors
Cyclophosphamide
Glucocorticoids
Immunosuppression
Mycophenolic acid
Journal
Journal of nephrology
ISSN: 1724-6059
Titre abrégé: J Nephrol
Pays: Italy
ID NLM: 9012268
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
15
02
2019
accepted:
21
03
2019
pubmed:
31
3
2019
medline:
10
9
2020
entrez:
31
3
2019
Statut:
ppublish
Résumé
Synthetic immunosuppressive drugs are largely used in immune-related renal diseases and in kidney transplantation. Most of these drugs have a low therapeutic index (the ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective), which means that the drug should be dosed carefully and the patient monitored frequently. In this review, we consider the categories of synthetic immunosuppressive agents more frequently and conventionally used in clinical nephrology: glucocorticoids, Aalkylating agents (cyclophosphamide, chlorambucil), purine synthesis inhibitors (azathioprine, mycophenolate salts) and calcineurin inhibitors (cyclosporine, tacrolimus). For each category the possible side effects will be reviewed, the general and specific measures to prevent or treat the adverse events will be suggested, and the more common mistakes that may increase the risk of toxicity will be described. However, the efficacy and safety of immunosuppressive agents depend not only on the pharmacologic characteristics of single drugs but can be influenced also by the clinical condition and genetic characteristics of the patient, by the typology and severity of the underlying disease and by the interaction with other concomitantly used drugs.
Identifiants
pubmed: 30927190
doi: 10.1007/s40620-019-00602-5
pii: 10.1007/s40620-019-00602-5
doi:
Substances chimiques
Immunosuppressive Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
851-870Références
Transplantation. 2013 Jun 27;95(12):1498-505
pubmed: 23778568
J Clin Endocrinol Metab. 2015 Jun;100(6):2171-80
pubmed: 25844620
J Heart Lung Transplant. 2010 May;29(5):509-16
pubmed: 20061166
Arch Dermatol. 2006 Jan;142(1):109-10
pubmed: 16415398
Clin Pharmacokinet. 2007;46(1):13-58
pubmed: 17201457
Transplantation. 2010 Dec 27;90(12):1450-7
pubmed: 21079551
Clin Pharmacokinet. 2010 Mar;49(3):141-75
pubmed: 20170205
Eur J Drug Metab Pharmacokinet. 2017 Apr;42(2):183-189
pubmed: 27677732
Gut. 1993 Aug;34(8):1081-5
pubmed: 8174958
J Am Soc Nephrol. 2009 May;20(5):1103-12
pubmed: 19369404
Transplantation. 2002 Mar 15;73(5):732-6
pubmed: 11907418
Eur J Gastroenterol Hepatol. 2004 Feb;16(2):207-12
pubmed: 15075996
Arthritis Rheum. 2005 Aug 15;53(4):528-35
pubmed: 16082633
QJM. 1996 Oct;89(10):751-63
pubmed: 8944231
Biochem Biophys Res Commun. 2015 May 1;460(2):157-63
pubmed: 25753204
Biochem Pharmacol. 2014 Mar 15;88(2):216-28
pubmed: 24462915
N Engl J Med. 2013 Apr 18;368(16):1477-88
pubmed: 23506003
J Immunol Res. 2017;2017:3149426
pubmed: 28194427
Clin J Am Soc Nephrol. 2018 May 7;13(5):815-822
pubmed: 29475991
Clin Lab. 2016;62(1-2):203-7
pubmed: 27012051
Life Sci. 2019 Feb 1;218:213-223
pubmed: 30605646
Life Sci. 1999;64(15):1295-306
pubmed: 10227585
Clin Dev Immunol. 2009;2009:681482
pubmed: 20052390
Am J Med. 2006 Jul;119(7 Suppl 1):S12-6
pubmed: 16843080
Cochrane Database Syst Rev. 2018 Jan 03;1:CD010908
pubmed: 29297205
Respiration. 1992;59(2):125-8
pubmed: 1620983
J Clin Med. 2018 Dec 15;7(12):
pubmed: 30558290
Ann Intern Med. 2004 Nov 16;141(10):764-70
pubmed: 15545676
Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007893
pubmed: 20091657
N Engl J Med. 2012 Jul 26;367(4):329-39
pubmed: 22830463
Eur J Endocrinol. 2007 Nov;157(5):545-59
pubmed: 17984234
BMC Res Notes. 2018 May 21;11(1):331
pubmed: 29784014
Pediatr Transplant. 2017 Nov;21(7):
pubmed: 28869324
Can J Cardiol. 2000 Apr;16(4):505-11
pubmed: 10787466
J Clin Endocrinol Metab. 2009 Aug;94(8):2692-701
pubmed: 19470627
Pharmacol Rep. 2016 Feb;68(1):201-5
pubmed: 26721374
Am J Transplant. 2017 Nov;17(11):2829-2840
pubmed: 28432716
Clin Rheumatol. 2013 Jul;32(7):1071-3
pubmed: 23456414
Lancet Diabetes Endocrinol. 2018 Mar;6(3):173-185
pubmed: 29229498
J Nephrol. 2017 Apr;30(2):155-157
pubmed: 28211033
Transplantation. 2005 Nov 27;80(10):1402-5
pubmed: 16340782
Am J Nephrol. 2013;37(6):602-12
pubmed: 23796509
Joint Bone Spine. 2011 Jan;78(1):41-4
pubmed: 20471889
Ann Rheum Dis. 2020 Feb;79(2):e23
pubmed: 30487148
Cochrane Database Syst Rev. 2016 Oct 05;10:CD001347
pubmed: 27706804
J Steroid Biochem Mol Biol. 1992 Oct;43(5):409-13
pubmed: 1390289
J Rheumatol. 2008 Jan;35(1):100-5
pubmed: 17937462
J Nephrol. 2005 Sep-Oct;18(5):521-8
pubmed: 16299677
Clin Pharmacol Ther. 2017 Jan;101(1):114-120
pubmed: 27804122
Transplant Rev (Orlando). 2017 Apr;31(2):69-77
pubmed: 27665059
Arthritis Rheumatol. 2017 Jun;69(6):1267-1271
pubmed: 28235250
PLoS One. 2016 Jun 29;11(6):e0158360
pubmed: 27355450
Gynecol Oncol. 1997 Apr;65(1):177-9
pubmed: 9103410
Clin Exp Gastroenterol. 2015 Jul 21;8:205-13
pubmed: 26229499
Rheumatol Int. 2008 Apr;28(6):567-71
pubmed: 17968551
Clin Transplant. 1998 Jun;12(3):198-205
pubmed: 9642510
J Clin Endocrinol Metab. 2009 May;94(5):1548-54
pubmed: 19223520
Pediatr Nephrol. 2001 Mar;16(3):271-82
pubmed: 11322378
Int J Dermatol. 2017 Apr;56(4):370-378
pubmed: 27868187
Clin Endocrinol (Oxf). 1983 Feb;18(2):155-66
pubmed: 6851197
J Am Acad Dermatol. 2017 Feb;76(2):191-198
pubmed: 28088990
Eur J Pharmacol. 2019 Mar 5;846:23-29
pubmed: 30639796
PLoS One. 2015 Nov 23;10(11):e0143405
pubmed: 26599323
Drugs. 2005;65(18):2593-611
pubmed: 16392875
World J Nephrol. 2017 Jul 6;6(4):217-220
pubmed: 28729970
Lupus. 1997;6(3):254-7
pubmed: 9104732
Trends Pharmacol Sci. 2019 Jan;40(1):38-49
pubmed: 30497693
Eur J Endocrinol. 2015 Oct;173(4):M11-21
pubmed: 25971647
Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1338-49
pubmed: 27150391
Best Pract Res Clin Endocrinol Metab. 2016 Dec;30(6):749-755
pubmed: 27974188
Adv Exp Med Biol. 2015;872:3-31
pubmed: 26215988
Metabolism. 2011 Nov;60(11):1500-10
pubmed: 21864867
Sci Rep. 2016 Jun 27;6:28648
pubmed: 27345868
Ann Nutr Metab. 2014;65(4):324-32
pubmed: 25402408
Kidney Int. 1994 Sep;46(3):647-52
pubmed: 7527873
Transplantation. 1998 Jun 27;65(12):1611-5
pubmed: 9665078
Nutr Res. 2014 Mar;34(3):179-90
pubmed: 24655484
Cancer. 1977 Apr;39(4):1403-9
pubmed: 851940
Allergy Asthma Clin Immunol. 2013 Aug 15;9(1):30
pubmed: 23947590
Transplantation. 2006 Aug 27;82(4):581
pubmed: 16926609
Hum Reprod. 2015 May;30(5):1089-101
pubmed: 25796551
Eur J Endocrinol. 2017 Aug;177(2):195-205
pubmed: 28566441
Med Clin (Barc). 2000 Sep 16;115(8):299-301
pubmed: 11093885
Br J Pharmacol. 2011 Jan;162(1):136-46
pubmed: 20825407
Am J Gastroenterol. 2003 Jun;98(6):1305-8
pubmed: 12818274
J Rheumatol. 2015 Sep;42(9):1661-6
pubmed: 26178288
Curr Vasc Pharmacol. 2004 Jan;2(1):1-12
pubmed: 15320828
Am J Hypertens. 1995 Aug;8(8):823-8
pubmed: 7576399
Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F489-F501
pubmed: 28003191
Medicine (Baltimore). 2016 Apr;95(14):e3173
pubmed: 27057842
Kidney Int. 2007 Dec;72(12):1429-47
pubmed: 17898700
Adv Exp Med Biol. 2015;872:179-215
pubmed: 26215995
Eur J Neurol. 2000 Jan;7(1):130
pubmed: 10809932
J Clin Gastroenterol. 2002 Sep;35(3):240-4
pubmed: 12192200
Autoimmun Rev. 2018 Oct;17(10):1022-1027
pubmed: 30107267
Cochrane Database Syst Rev. 2007 Oct 17;(4):CD003982
pubmed: 17943809
Drug Metab Rev. 2016;48(1):88-112
pubmed: 26912097
Curr Hypertens Rep. 2002 Oct;4(5):377-80
pubmed: 12217256
Adv Clin Exp Med. 2016 May-Jun;25(3):479-84
pubmed: 27629736
Expert Rev Clin Immunol. 2015 May;11(5):549-52
pubmed: 25842985
Br J Clin Pharmacol. 2010 Dec;70(6):844-53
pubmed: 21175440
Nephrol Dial Transplant. 1999 Jan;14(1):91-7
pubmed: 10052484
Aliment Pharmacol Ther. 2013 Nov;38(9):1025-37
pubmed: 24099468
Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):547-57
pubmed: 25614279
Kidney Int. 1996 Oct;50(4):1089-100
pubmed: 8887265
Semin Nephrol. 2003 Sep;23(5):465-76
pubmed: 13680536
J Biol Chem. 2013 Feb 1;288(5):3477-88
pubmed: 23258544
Mol Metab. 2017 Oct;6(10):1150-1160
pubmed: 29031716
Clin J Am Soc Nephrol. 2009 Feb;4(2):481-508
pubmed: 19218475
Nephron Clin Pract. 2011;117(1):c8-14
pubmed: 20689319
Transpl Int. 2004 Nov;17(10):609-16
pubmed: 15517170
Transplantation. 1998 Aug 15;66(3):409
pubmed: 9721817
J Periodontal Res. 2012 Apr;47(2):137-48
pubmed: 22050485
PLoS One. 2015 May 14;10(5):e0126016
pubmed: 25973882
Nephrol Dial Transplant. 2016 Nov;31(11):1957-1965
pubmed: 27604074
Autoimmun Rev. 2014 Jul;13(7):723-9
pubmed: 24657897
Nephrol Dial Transplant. 1996 Jul;11(7):1371-3
pubmed: 8672045
Expert Opin Drug Metab Toxicol. 2017 May;13(5):525-536
pubmed: 28019118
Arthritis Rheum. 2006 Feb;54(2):628-34
pubmed: 16447241
Curr Opin Organ Transplant. 2014 Apr;19(2):201-8
pubmed: 24553497
Curr Opin Cardiol. 2002 Sep;17(5):531-6
pubmed: 12357131
Crit Care Clin. 2019 Jan;35(1):169-186
pubmed: 30447778
Transplant Proc. 2010 Oct;42(8):2910-3
pubmed: 20970568
Can J Physiol Pharmacol. 2014 Feb;92(2):140-8
pubmed: 24502637
N Engl J Med. 2018 Dec 27;379(26):2547-2556
pubmed: 30586507
Nephrol Dial Transplant. 2014 Apr;29 Suppl 2:i1-i39
pubmed: 24569496
Ther Adv Chronic Dis. 2018 Jun 13;9(9):179-190
pubmed: 30181847
Mol Cell Biochem. 2017 May;429(1-2):179-185
pubmed: 28324237
Clin Cornerstone. 2009;9(4):55-68; discussion 69-71
pubmed: 19789064
Rheumatology (Oxford). 2012 Jun;51(6):1112-9
pubmed: 22332121
PLoS One. 2015 Jun 26;10(6):e0131394
pubmed: 26114497
Case Rep Dermatol. 2017 Jan 19;9(1):6-11
pubmed: 28203157
N Engl J Med. 2019 Jan 3;380(1):11-22
pubmed: 30415628
Arch Intern Med. 2009 Oct 12;169(18):1677-83
pubmed: 19822824
Toxicol Pathol. 2012;40(2):267-71
pubmed: 22105649
Transplantation. 2004 Oct 27;78(8):1204-11
pubmed: 15502721
Rev Infect Dis. 1989 Nov-Dec;11(6):954-63
pubmed: 2690289
Prog Transplant. 2013 Jun;23(2):137-46
pubmed: 23782661
J Med Case Rep. 2012 Nov 30;6:413
pubmed: 23198815
PLoS One. 2013 Nov 15;8(11):e81702
pubmed: 24260584
J Intern Med. 1994 Dec;236(6):619-32
pubmed: 7989897
Nature. 1992 Jun 25;357(6380):692-4
pubmed: 1377361
Nephrol Dial Transplant. 2007 Feb;22(2):671-2
pubmed: 16980323
J Clin Pharmacol. 1997 Apr;37(4):304-11
pubmed: 9115056
Am J Physiol Renal Physiol. 2015 Sep 1;309(5):F474-83
pubmed: 26109089
World J Gastroenterol. 2015 Jul 7;21(25):7795-804
pubmed: 26167079
Nephrol Dial Transplant. 2002 May;17(5):923-6
pubmed: 11981085
Pediatr Blood Cancer. 2009 Aug;53(2):261-6
pubmed: 19326418
Scand J Gastroenterol. 2017 Aug;52(8):876-880
pubmed: 28388864