Mammary cancer risk and serum lipid profile of rats supplemented with pomegranate seed oil and bitter melon extract.
Animals
Body Weight
/ drug effects
Carcinogenesis
/ drug effects
Dietary Supplements
Dinoprost
/ analogs & derivatives
Dose-Response Relationship, Drug
Fatty Acids
/ blood
Female
Mammary Neoplasms, Experimental
/ blood
Momordica charantia
/ chemistry
Organ Size
/ drug effects
Plant Oils
/ pharmacology
Pomegranate
/ chemistry
Rats
Rats, Sprague-Dawley
Risk
Seeds
/ chemistry
Animal models
Breast cancer
Diet
Journal
Prostaglandins & other lipid mediators
ISSN: 1098-8823
Titre abrégé: Prostaglandins Other Lipid Mediat
Pays: United States
ID NLM: 9808648
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
16
11
2018
revised:
31
01
2019
accepted:
25
03
2019
pubmed:
1
4
2019
medline:
28
1
2020
entrez:
1
4
2019
Statut:
ppublish
Résumé
The objective of the present study was to determine the influence of dietary supplementation with pomegranate seed oil (PSO) and/or an aqueous extract of dried bitter melon fruits (BME) on breast cancer risk and fatty acid profile in serum of female rats with chemical carcinogen-inflicted mammary tumours. Sprague-Dawley rats (n = 96) were fed control diet or experimental diets supplemented with 0.15 ml PSO/day, BME or jointly PSO and BME. After 21 weeks mammary tumours were subjected to histopathological examination and in serum fatty acids, 8-isoprostaglandin F
Identifiants
pubmed: 30928411
pii: S1098-8823(18)30157-6
doi: 10.1016/j.prostaglandins.2019.03.005
pii:
doi:
Substances chimiques
Fatty Acids
0
Plant Oils
0
8-epi-prostaglandin F2alpha
27415-26-5
Dinoprost
B7IN85G1HY
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
33-45Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.