Disseminated Mycosis by Arthrocladium fulminans Jeopardizing a Patient with GATA2 Deficiency.
Antifungal Agents
/ administration & dosage
Brain
/ diagnostic imaging
Bronchoscopy
/ methods
Clinical Deterioration
Fatal Outcome
Female
Fungi
/ isolation & purification
GATA2 Deficiency
/ diagnosis
GATA2 Transcription Factor
/ genetics
Humans
Immunologic Deficiency Syndromes
/ blood
Invasive Fungal Infections
/ diagnosis
Lung
/ diagnostic imaging
Mutation
Tomography, X-Ray Computed
/ methods
Young Adult
Arthrocladium fulminans
GATA2
Immunodeficiency syndrome
Melanized fungus
MonoMAC
Mycobacterium sherrisii
Journal
Respiration; international review of thoracic diseases
ISSN: 1423-0356
Titre abrégé: Respiration
Pays: Switzerland
ID NLM: 0137356
Informations de publication
Date de publication:
Historique:
received:
01
06
2018
accepted:
28
08
2018
pubmed:
1
4
2019
medline:
22
9
2020
entrez:
1
4
2019
Statut:
ppublish
Résumé
GATA2 deficiency is characterized by monocytopenia, deficiency of dendritic cells, and a variable degree of lymphocytopenia affecting B cells and NK cells, leading to an enhanced risk of mycobacterial, viral, and fungal infections. Here we present a patient with a heterozygous intronic GATA2 mutation who acquired a fatal disseminated mycosis due to the black yeast-like fungus Arthrocladium fulminans following an infection with Mycobacterium sherrisii. This case illustrates that in patients with severe uncommon infections, immunodeficiency syndromes must be ruled out.
Identifiants
pubmed: 30928982
pii: 000493429
doi: 10.1159/000493429
doi:
Substances chimiques
Antifungal Agents
0
GATA2 Transcription Factor
0
GATA2 protein, human
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
472-475Informations de copyright
© 2019 S. Karger AG, Basel.