Cutaneous histopathology of the tick-bite region in severe fever with thrombocytopenia syndrome.
CD20
hemophagocytosis
immunoblastic cells
severe fever with thrombocytopenia syndrome
skin biopsy
Journal
The Journal of dermatology
ISSN: 1346-8138
Titre abrégé: J Dermatol
Pays: England
ID NLM: 7600545
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
13
12
2018
accepted:
26
02
2019
pubmed:
2
4
2019
medline:
27
8
2019
entrez:
2
4
2019
Statut:
ppublish
Résumé
A case of severe fever with thrombocytopenia syndrome (SFTS) in which a skin biopsy from the tick-bite region was analyzed is reported. The patient was a 72-year-old woman who developed fever and thrombocytopenia after a tick bite. SFTS was diagnosed from polymerase chain reaction (PCR) analysis of a blood sample. Histopathological analysis of a skin biopsy specimen from the tick-bite region showed CD20-positive perivascular and interstitial immunoblastic cells, which were positive to anti-SFTS virus (SFTSV) nucleoprotein antibody. In addition, SFTSV RNA was detected by real-time PCR from this biopsy specimen. Moreover, hemophagocytosis was also found in the tick-bite region. To the best of our knowledge, this is the first report to analyze the details of the tick-bite region of skin in SFTS, and the first to detect virus-infected cells in the skin. The present findings may help elucidate the mechanisms of entry of SFTSV.
Identifiants
pubmed: 30932227
doi: 10.1111/1346-8138.14862
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Case Reports
Journal Article
Langues
eng
Pagination
409-412Informations de copyright
© 2019 Japanese Dermatological Association.