Determination of terbinafine in human plasma using UPLC-MS/MS: Application to a bioequivalence study in healthy subjects.

Chromatography, High Pressure Liquid / methods Female Humans Limit of Detection Linear Models Liquid-Liquid Extraction Male Reproducibility of Results Tandem Mass Spectrometry / methods Terbinafine / blood Therapeutic Equivalency
UPLC-MS/MS bioequivalence study human plasma liquid-liquid extraction terbinafine terbinafine-d7

Journal

Biomedical chromatography : BMC
ISSN: 1099-0801
Titre abrégé: Biomed Chromatogr
Pays: England
ID NLM: 8610241

Informations de publication

Date de publication:
Aug 2019
Historique:
received: 29 11 2018
revised: 11 03 2019
accepted: 26 03 2019
pubmed: 2 4 2019
medline: 6 8 2019
entrez: 2 4 2019
Statut: ppublish

Résumé

A high-throughput and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed for the determination of terbinafine in human plasma. The method employed liquid-liquid extraction of terbinafine and terbinafine-d7 (used as internal standard) from 100 μL human plasma with ethyl acetate-n-hexane (80:20, v/v) solvent mixture. Chromatography was performed on a BEH C

Identifiants

DOI: 10.1002/bmc.4543 PMID: 30933360
pubmed: 30933360
doi: 10.1002/bmc.4543
doi:

Substances chimiques

Terbinafine G7RIW8S0XP

Types de publication

Journal Article

Langues

eng

Pagination

e4543

Informations de copyright

© 2019 John Wiley & Sons, Ltd.

Auteurs

Abhaysingh Bhadoriya (A)

Kadi Sarva Viswavidyalaya, Sector-15, Ghandhinagar, 382715, Gujarat, India.

Priyanka A Shah (PA)

Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, 380009, India.

Pranav S Shrivastav (PS)

Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, 380009, India.
ORCID: 0000-0002-1284-1558

Kirtikumar D Bharwad (KD)

Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, 380009, India.

Puran Singhal (P)

Bioanalytical Department, Alkem Laboratories Ltd., Lower Parel, Mumbai, 400013, India.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Determination of terbinafine in human plasma...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Determination of terbinafine in human plasma...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Sensibilité et spécificité › Limite de détection › Determination of terbinafine in human plasma...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › Modèles linéaires › Determination of terbinafine in human plasma...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Fractionnement chimique › Extraction liquide-liquide › Determination of terbinafine in human plasma...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Determination of terbinafine in human plasma...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Determination of terbinafine in human plasma...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Terbinafine › Determination of terbinafine in human plasma...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Équivalence thérapeutique › Determination of terbinafine in human plasma...