Gamma-oryzanol Prevents LPS-induced Brain Inflammation and Cognitive Impairment in Adult Mice.
cognitive performance
neuroinflammation
second-generation antioxidant enzymes
γ-oryzanol
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
29 Mar 2019
29 Mar 2019
Historique:
received:
13
02
2019
revised:
19
03
2019
accepted:
26
03
2019
entrez:
3
4
2019
pubmed:
3
4
2019
medline:
7
8
2019
Statut:
epublish
Résumé
Rice ( Mice received 100 mg/kg γ-oryzanol (ORY) or vehicle once daily for 21 consecutive days and were then exposed to an inflammatory stimulus elicited by lipopolysaccharide (LPS). A novel object recognition test and mRNA expression of antioxidant and neuroinflammatory markers in the hippocampus were evaluated. ORY treatment was able to improve cognitive performance during the neuroinflammatory response. Furthermore, phase II antioxidant enzymes such as heme oxygenase-1 (HO-1) and NADPH-dehydrogenase-quinone-1 (NQO1) were upregulated in the hippocampi of ORY and ORY+LPS mice. Lastly, γ-oryzanol showed a strong anti-inflammatory action by downregulating inflammatory genes after LPS treatment. These results suggest that chronic consumption of γ-oryzanol can revert the LPS-induced cognitive and memory impairments by promoting hippocampal antioxidant and anti-inflammatory molecular responses.
Sections du résumé
BACKGROUND
BACKGROUND
Rice (
METHODS
METHODS
Mice received 100 mg/kg γ-oryzanol (ORY) or vehicle once daily for 21 consecutive days and were then exposed to an inflammatory stimulus elicited by lipopolysaccharide (LPS). A novel object recognition test and mRNA expression of antioxidant and neuroinflammatory markers in the hippocampus were evaluated.
RESULTS
RESULTS
ORY treatment was able to improve cognitive performance during the neuroinflammatory response. Furthermore, phase II antioxidant enzymes such as heme oxygenase-1 (HO-1) and NADPH-dehydrogenase-quinone-1 (NQO1) were upregulated in the hippocampi of ORY and ORY+LPS mice. Lastly, γ-oryzanol showed a strong anti-inflammatory action by downregulating inflammatory genes after LPS treatment.
CONCLUSION
CONCLUSIONS
These results suggest that chronic consumption of γ-oryzanol can revert the LPS-induced cognitive and memory impairments by promoting hippocampal antioxidant and anti-inflammatory molecular responses.
Identifiants
pubmed: 30934852
pii: nu11040728
doi: 10.3390/nu11040728
pmc: PMC6520753
pii:
doi:
Substances chimiques
Antioxidants
0
Lipopolysaccharides
0
Phenylpropionates
0
gamma-oryzanol
SST9XCL51M
Types de publication
Journal Article
Langues
eng
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