Identification of Insulin-Responsive Transcription Factors That Regulate Glucose Production by Hepatocytes.
Animals
Forkhead Transcription Factors
/ genetics
Gene Expression Regulation
Gene Knockdown Techniques
Gluconeogenesis
/ genetics
Glucose-6-Phosphatase
/ genetics
Hepatocytes
/ metabolism
Insulin
/ metabolism
Intracellular Signaling Peptides and Proteins
/ genetics
Liver
/ metabolism
Mice
Phosphoenolpyruvate Carboxykinase (GTP)
/ genetics
Primary Cell Culture
Transcription Factors
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
20
11
2018
accepted:
20
03
2019
pubmed:
3
4
2019
medline:
24
12
2019
entrez:
3
4
2019
Statut:
ppublish
Résumé
Hepatocyte glucose production is a complex process that integrates cell-autonomous mechanisms with cellular signaling, enzyme activity modulation, and gene transcription. Transcriptional mechanisms controlling glucose production are redundant and involve nuclear hormone receptors and unliganded transcription factors (TFs). Our knowledge of this circuitry is incomplete. Here we used DNA affinity purification followed by mass spectrometry to probe the network of hormone-regulated TFs by using phosphoenolpyruvate carboxykinase (
Identifiants
pubmed: 30936148
pii: db18-1236
doi: 10.2337/db18-1236
pmc: PMC6610019
doi:
Substances chimiques
Forkhead Transcription Factors
0
Foxk1 protein, mouse
0
Insulin
0
Intracellular Signaling Peptides and Proteins
0
Transcription Factors
0
Glucose-6-Phosphatase
EC 3.1.3.9
Pck1 protein, mouse
EC 4.1.1.32
Phosphoenolpyruvate Carboxykinase (GTP)
EC 4.1.1.32
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1156-1167Subventions
Organisme : NIDDK NIH HHS
ID : R37 DK058282
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK064819
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK057539
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK063618
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063608
Pays : United States
Informations de copyright
© 2019 by the American Diabetes Association.
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