Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer.
Cell Line, Tumor
Citric Acid Cycle
Fibroblasts
/ pathology
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
/ metabolism
Male
Mitochondria
/ metabolism
NAD
/ metabolism
Neoplasm Invasiveness
Oxidative Phosphorylation
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
/ metabolism
Prostatic Neoplasms
/ metabolism
Reactive Oxygen Species
/ metabolism
Sirtuin 1
/ metabolism
Journal
Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
30
07
2018
accepted:
20
03
2019
revised:
12
03
2019
pubmed:
3
4
2019
medline:
15
2
2020
entrez:
3
4
2019
Statut:
ppublish
Résumé
Cancer-associated fibroblasts (CAFs) are the major cellular stromal component of many solid tumors. In prostate cancer (PCa), CAFs establish a metabolic symbiosis with PCa cells, contributing to cancer aggressiveness through lactate shuttle. In this study, we report that lactate uptake alters the NAD
Identifiants
pubmed: 30936458
doi: 10.1038/s41388-019-0805-7
pii: 10.1038/s41388-019-0805-7
doi:
Substances chimiques
HIF1A protein, human
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
PPARGC1A protein, human
0
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
0
Reactive Oxygen Species
0
NAD
0U46U6E8UK
SIRT1 protein, human
EC 3.5.1.-
Sirtuin 1
EC 3.5.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5339-5355Références
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